Results 71 to 80 of about 148,561 (252)

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel

Stroke and Vascular Neurology
Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients, in part because of treatment resistance. The primary aim was to assess the proportion of patients who are insensitive to clopidogrel.
Philip M Bath, Nikola Sprigg, Jason Philip Appleton, Carla Richardson, Natalia Dovlatova, Jane May, Stan Heptinstall   +6 more
doaj   +1 more source

Changes in Practice Patterns of Clopidogrel in Combination with Proton Pump Inhibitors after an FDA Safety Communication.

PLoS ONE, 2016
ObjectivesIn 2009, the FDA issued a warning that omeprazole--a proton pump inhibitor (PPI)--reduces the antithrombotic effect of clopidogrel by almost half when taken concomitantly.
Annie Guérin, Reema Mody, Valerie Carter, Charles Ayas, Haridarshan Patel, Karen Lasch, Eric Wu   +6 more
doaj   +1 more source

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

ESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli, François Roubille, Nicolas Meyer, Giulio Pompilio, Lionel Leroux, Philippe Henon, Guillaume Trebuchet, Anthony Criquet, Matthieu de Kalbermatten, Eric Saloux, Alain Manrique, Pierre‐Yves Marie, Deepak L. Bhatt, Scott D. Solomon, Gilles Montalescot, David E. Newby, Faiez Zannad, on behalf of the EXCELLENT Trial Investigators   +17 more
wiley   +1 more source

Evaluation ofAaspirin, Clopidogrel or Their Combination In Hypertensive Patients

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2010
The objective of this study is to evaluate the effect of aspirin, clopidogrel or their combination on different parameters in hypertensive patients.
Fadia Y. Al-hamdani, Maitham M. Al-mefraji   +1 more
doaj   +1 more source

Electrochemical Three‐Component Synthesis of Heteroaryl Sulfonates

European Journal of Organic Chemistry, EarlyView.
An electrochemical, metal‐free three‐component strategy for direct C(sp2)─H sulfonation of electron‐rich heteroarenes using SO2 and alcohols is described. Utilizing inexpensive graphite electrodes and practical SO2 stock solutions under mild conditions, this method provides straightforward access to heteroaryl sulfonates from simple building blocks ...
Po‐Chung Chien, Harald Kelm, Georg Manolikakes   +2 more
wiley   +1 more source

Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites

, 2012
Ticlopidine and clopidogrel are thienopyridine derivatives used for inhibition of platelet aggregation. Not only hepatotoxicity, but also bone marrow toxicity may limit their use.
Brecht, Karin, Maseneni, Swarna, Krähenbühl, Stephan, Donzelli, Massimiliano, Taegtmeyer, A. B., Taegtmeyer, Anne Barbara   +5 more
core   +1 more source

Food‐grade proteins, lipids, and fibers as potential tools to ameliorate cardiovascular disorders: A review

Food Biomacromolecules, EarlyView.
Abstract Cardiovascular diseases (CVDs) remain the leading cause of global mortality, necessitating effective preventive and adjunct therapeutic strategies beyond conventional pharmacological interventions. Although previous reviews have focused on individual nutrients or dietary patterns, this review provides a mechanism‐based, integrative perspective
Sridevi Shanmugam, Rukaiah Fatma Begum, Nirenjen Shanmugasundaram, Bhupendra Gopalbhai Prajapati, Suresh Ankul Singh, Pavithra Nagenthran, Sudarshan Singh, Kesarla Rajesh   +7 more
wiley   +1 more source

Evaluation of clopidogrel responsiveness using the Platelet Function Analyzer-200 (PFA-200) in dogs

Frontiers in Veterinary Science
We aimed to evaluate the prevalence of clopidogrel resistance in hypercoagulable dogs using the Platelet Function Analyzer-200 (PFA-200) P2Y cartridge; further, we aimed to assess the utility of hematocrit (HCT), platelet count (PLT), prothrombin time ...
Joon-Ho Shin, Hyun-Jung Han, Hyun-Jung Han   +2 more
doaj   +1 more source

THE EFFECTIVENESS OF CLOPIDOGREL AS AN ANTITHROMBOTIC COMPARED TO TICLOPIDINE AND ASPIRIN (META-ANALYSIS)

Jurnal Farmasi Sains dan Komunitas, 2017
Clopidogrel, an antithrombotic drug, has been proven by FDA as Plavix® was initially used for the prevention of vascular occlusive that cause of myocardial infarction, stroke, and vascular death in patients with atherosclerosis and then it is used to ...
Titien Siwi Hartayu, Dewi Setyaningsih
doaj   +1 more source