Results 131 to 140 of about 148,561 (252)

Backrest Position and Outcome in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Protocol for a Multi‐Center Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest (DANOHCA) Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Intensive care following resuscitation from out‐of‐hospital cardiac arrest (OHCA) is based on a set of interventions, all of which are intended to reduce anoxic brain injury and improve outcomes, including sedation, mechanical ventilation, circulatory optimization, and temperature control protocols.
Jesper Kjaergaard, Jo Bønding Andreasen, Simon Mølstrøm, Bodil Steen Rasmussen, Steffen Christensen, Henrik Schmidt, Jacob Eifer Moeller, Lars Peter Kloster Andersen, Sören Möller, Christian Hassager, Martin A. S. Meyer, Simon Schneekloth, Laust Obling, Anders Morten Grejs   +13 more
wiley   +1 more source

Clopidogrel Management in Abdominal Surgery: A Comparison of Perioperative Bleeding Risks with Low-Molecular-Weight Heparin Bridging, No-Bridging and Clopidogrel Continuation Strategies

Clinical and Applied Thrombosis/Hemostasis
Clopidogrel is usually discontinued 5–7 days before elective surgery to reduce the risk of bleeding. However, the perioperative safety of patients receiving low-molecular-weight heparin (LMWH) bridging therapy or continuing clopidogrel therapy remains ...
Bangsheng Hu MD, Junsheng Chen MD, Shuai Han MD, Zeping Dai MD, PhD, Ju Gao MD, PhD   +4 more
doaj   +1 more source

CYP2C19 Polymorphism and Platelet Aggregation-Associated Risks in Atrial Fibrillation Patients Undergoing PCI. [PDF]

Clin Transl Sci
ABSTRACT CYP2C19 genetic polymorphisms impact the antiplatelet effect of clopidogrel and associate with ischemic and bleeding risk in patients undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the association of CYP2C19 and platelet reactivity (PR) with these risks, in atrial fibrillation (AF) patients undergoing PCI ...
Gjermeni D, Szabó S, Anfang V, Vetter H, Juelch C, Rademacher S, Li T, Leggewie S, Hesselbarth D, Duerschmied D, Trenk D, Westermann D, Olivier CB.   +12 more
europepmc   +2 more sources

Modern role for clopidogrel in management of atrial fibrillation and stroke reduction

, 2010
Lars Maegdefessel, Junya Azuma, Philip S TsaoDepartment of Cardiovascular Medicine, School of Medicine, Stanford University, CA, USAAbstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The prevalence of AF increases sharply
Lars Maegdefessel, Philip S Tsao, Junya Azuma   +2 more
core  

Dexamethasone Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Study Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest Trial (DANOHCA)

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background The inflammatory response to whole‐body ischemia, as seen in comatose survivors after out‐of‐hospital cardiac arrest (OHCA), is associated with increased morbidity and mortality. Early high‐dose dexamethasone may dampen the inflammatory response, which may diminish secondary brain damage and other organ injury and decrease mortality.
Jo B. Andreasen, Anders Morten Grejs, Simon Mölström, Lars P. K. Andersen, Sören Möller, Steffen Christensen, Henrik Schmidt, Jacob E. Møller, Martin A. S. Meyer, Jesper Kjærgaard, Alexander W. Erbs, Bodil S. Rasmussen, Christian Hassager   +12 more
wiley   +1 more source

Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest (DANOHCA) Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Delirium is a frequent complication in comatose Out‐of‐Hospital Cardiac Arrest (OHCA) survivors requiring postresuscitation intensive care and is associated with higher mortality and longer hospitalization. Despite this, there is no established pharmacologic strategy for delirium prevention in OHCA survivors.
Benedikte Liebetrau, Anders M. Grejs, Martin A. S. Meyer, Lars P. K. Andersen, Sören Möller, Simon Mølstrøm, Jacob E. Møller, Henrik Schmidt, Steffen Christensen, Jesper Kjærgaard, Christian Hassager, Bodil S. Rasmussen, Jo B. Andreasen   +12 more
wiley   +1 more source

The effect of concurrent clopidogrel and omeprazole administration on clopidogrel metabolism and platelet function in healthy cats

Journal of Veterinary Internal Medicine
Background Some studies in humans show that the concurrent use of clopidogrel and omeprazole decreases plasma clopidogrel active metabolite (CAM) concentrations and clopidogrel antiplatelet effects. Whether this drug interaction occurs in cats is unknown.
Christina Plante, Pamela M. Lee, Jillian M. Haines, O. Lynne Nelson, Stephanie E. Martinez, Michael H. Court   +5 more
doaj   +1 more source

Analysis of interstitial lung disease in pharmacovigilance databases: Coding challenges and interpretation biases—An update

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2147-2161, July 2026.
Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel, Adeline Benis, Philippe Bonniaud, Jean‐Luc Faillie, Aurélie Grandvuillemin   +4 more
wiley   +1 more source

Suspected clopidogrel-associated hepatitis in a cat

Journal of Feline Medicine and Surgery Open Reports
Case summary Acute hepatitis and liver damage are rare adverse effects of clopidogrel in humans. In veterinary medicine, clopidogrel is mainly prescribed in the treatment of feline patients with cardiomyopathies.
Astrid L Kamp, Washma Yousofzai, Hans S Kooistra, Giorgia Santarelli, Ingeborg M van Geijlswijk   +4 more
doaj   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2203-2211, July 2026.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres, Justyna Wozniak, Hannah Fölsch, Anja Knueppel‐Ruppert, Verena Graeff, Andrea Kriegisch‐Stumpf, Harald Dormann, Julia C. Stingl, Katja S. Just   +8 more
wiley   +1 more source