Results 131 to 140 of about 156,135 (207)

Response to "Very late stent thrombosis after discontinuation of clopidogrel therapy" by Conroy MM, Bolsin SNC.

open access: yes, 2009
The recent article by Barthwal and Herman highlights the problem of late stent thrombosis in a patient with a drug-eluting stent (DES) undergoing non-cardiac surgery (NCS).1 While the authors stated that clopidogrel therapy was ceased preoperatively and ...
Pattullo, S, Jayasinghe, Satyajit
core  

Natural History and Factors Influencing 90‐Day Clinical Outcomes and 1‐Year Recurrence of Thalamic Stroke

open access: yesBrain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Objective To investigate the natural course of cerebral small vessel disease (CSVD) manifested as pure thalamic infarction (PTI) and identify predictors of 90‐day clinical prognosis and 1‐year recurrent major adverse cardiovascular/cerebrovascular events (MACE).
Huang Qiang, Cui Ying, Zhang Yongbo
wiley   +1 more source

Clinical update on the therapeutic use of clopidogrel: treatment of acute ST-segment elevation myocardial infarction (STEMI)

open access: yes, 2006
Huyen Tran1, Shamir R Mehta2, John W Eikelboom21Department of Clinical Haematology, Monash Medical Centre, Victoria, Australia; 2Department of Medicine, McMaster University, Hamilton, CanadaAbstract: The pathogenesis of ST-elevation myocardial infarction
Huyen Tran   +2 more
core  

Eupatilin Alleviates Acute Myocardial Ischemia‐Reperfusion Injury in Rats via the Akt/GSK‐3β Pathway by Targeting COXs

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
It has been reported that eupatilin exerts cardioprotective effects after myocardial ischemia‐reperfusion injury (MIRI). This study further found that Eupatilin alleviated acute MIRI in rats by specifically inhibiting cyclooxygenase enzymes (COXs) and activating the Akt/GSK‐3β pathway, providing a theoretical basis for the application of eupatilin in ...
Min Guo, Qianqian Li, Lili Ji
wiley   +1 more source

Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention

open access: yes, 2009
Nicholas B Norgard,1 Mazen Abu-Fadel21University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, USA; 2University of Oklahoma Health Sciences Center, Cardiovascular Section, Oklahoma City, OK, USAAbstract: Antiplatelet agents are
Mazen Abu-Fadel, Nicholas B Norgard
core  

Safety of Nonsteroidal Anti‐Inflammatory Drug Use in Traumatic Brain Injury

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background Use of nonsteroidal anti‐inflammatory drugs (NSAIDs) after a traumatic brain injury (TBI) is controversial due to potential worsening of an intracranial hemorrhage (ICH). This study evaluated if NSAID use within 14 days of TBI was associated with a clinically significant progression of intracranial bleed (PIB).
Jennifer Beavers   +10 more
wiley   +1 more source

Modern role for clopidogrel in management of atrial fibrillation and stroke reduction

open access: yes, 2010
Lars Maegdefessel, Junya Azuma, Philip S TsaoDepartment of Cardiovascular Medicine, School of Medicine, Stanford University, CA, USAAbstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The prevalence of AF increases sharply
Lars Maegdefessel   +2 more
core  

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 20, Page 5999-6006, October 2026.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Clopidogrel and vascular disease prevention

open access: yes
In this editorial we consider some aspects of the use of clopidogrel in current clinical practice. Clopidogrel has replaced ticlopidine as an alternative to aspirin. Among the problems with the use of antiplatelet agents is aspirin intolerance.
Mikhailidis DP   +2 more
core   +3 more sources

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

open access: yesClinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju   +6 more
wiley   +1 more source

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