Clopidogrel use is associated with an increased prevalence of Parkinson's disease, particularly among US adults with diabetes. [PDF]
Zhan J +8 more
europepmc +1 more source
Both transient ischaemic attack (TIA) and ischaemic stroke lead to an increase in individual cellular‐derived populations of extracellular vesicles (EVs), including endothelial, platelet and leukocyte derived. These EVs have downstream roles in the pathophysiological events associated with TIA and stroke, including dysregulated inflammation and ...
Rebecca Marie Raven +3 more
wiley +1 more source
Efficacy and safety of clopidogrel and aspirin in patients with chronic coronary syndrome: a systematic review and meta-analysis. [PDF]
Wei X, Yang Z, Chen M, Lu H, Hou S.
europepmc +1 more source
ABSTRACT Introduction The management of extremity soft tissue sarcomas (STS) involving major vessels presents unique challenges, historically leading to amputation. Advances in vascular reconstruction have enabled limb‐sparing surgery (LSS), but outcomes and perioperative risks remain uncertain.
Lucas Monteiro Delgado +9 more
wiley +1 more source
Rebound Phenomenon of Platelet Reactivity After Cessation of Long-Term Clopidogrel Therapy. [PDF]
Han JK +7 more
europepmc +1 more source
Empirical Comparison of Exposure Set Definitions in the Prevalent New‐User Design
ABSTRACT Purpose Prevalent new‐user (PNU) designs aim to provide a wider assessment of treatment effects by incorporating users of a newer study drug who previously received the comparator. Similarity in terms of prior use of the comparator is accounted for via exposure sets based on time in study, prior prescription number, or a hybrid incorporating ...
John Tazare +8 more
wiley +1 more source
Clopidogrel versus aspirin monotherapy following dual antiplatelet therapy after percutaneous coronary intervention: an updated meta-analysis of 162,829 patients. [PDF]
Elbahloul MA +7 more
europepmc +1 more source
Antiplatelet dilemma: Clopidogrel or aspirin for long-term cardiovascular protection after dual antiplatelet therapy following PCI. [PDF]
Moawad MHED +16 more
europepmc +1 more source
The potential of artificial intelligence in clinical trials
Artificial intelligence has the potential to transform many areas of clinical trials. Abstract Background Clinical trials are an important part of evidence generation in medicine but remain burdened by escalating costs, inefficiencies and manual processes.
Rahul Aggarwal, Deepak L. Bhatt
wiley +1 more source
Impact of antiplatelet therapy on the hemostatic efficacy of platelet-targeted FVIII gene therapy in hemophilia A mice. [PDF]
Yu H +4 more
europepmc +1 more source

