Results 51 to 60 of about 83,682 (305)

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Detection of Four Intermediate-mass Stars with Cool Companions in Low Mass Ratio Eclipsing Binaries

The Astrophysical Journal
According to the core fragmentation and dynamical capture theories of binary formation, binaries tend to form with nearly equal masses. The detection of intermediate-mass binaries with low mass ratios challenges these theories, as such binaries may form ...
Linfeng Chang, Shengbang Qian, Lei Zang, Fuxing Li   +3 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Can the Central Compact Object in HESS J1731–347 Be Indeed the Lightest Neutron Star Observed?

The Astrophysical Journal
The exceptionally low mass of $0.7{7}_{-0.17}^{+0.2}{M}_{\odot }$ for the central compact object (CCO) XMMU J173203.3–344518 (XMMU J1732) in the supernova remnant (SNR) HESS J1731–347 challenges standard neutron star (NS) formation models.
S. R. Zhang, J. A. Rueda Hernandez, R. Negreiros   +2 more
doaj   +1 more source

Impact of Binary Stars on Planet Statistics -- I. Planet Occurrence Rates, Trends with Stellar Mass, and Wide Companions to Hot Jupiter Hosts [PDF]

, 2019
Close binaries suppress the formation of circumstellar (S-type) planets and therefore significantly bias the inferred planet occurrence rates and statistical trends.
M. Moe, K. Kratter
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Radial Velocity Studies of Close Binary Stars. VI. [PDF]

, 1999
Radial velocity measurements and sine-curve fits to the orbital velocity variations are presented for the sixth set of 10 close binary systems: SV Cam, EE Cet, KR Com, V410 Cyg, GM Dra, V972 Her, ET Leo, FS Leo, V2388 Oph, and II UMa.
S. Rucinski, T. Pribulla, S. Mochnacki, Evgenij Liokumovich, Wen-xian Lu, H. DeBond, Archie de Ridder, T. Karmo, Matt Rock, J. Thomson, W. Ogłoza, Krysztof Kaminski, P. Ligeza   +12 more
semanticscholar   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Detecting New Visual Binaries in Gaia DR3 with Gaia and Two Micron All Sky Survey (2MASS) Photometry. II. Speckle Observations of 16 Low-separation Systems

The Astronomical Journal
Here we present speckle observations of 16 low-separation ( s < 30 au) high-probability candidate binaries from the catalog by Medan et al., where secondaries typically lack astrometric solutions in Gaia. From these speckle observations, we find a second
Ilija Medan, Sébastien Lépine, Zachary Hartman, Keivan G. Stassun   +3 more
doaj   +1 more source

THE CLOSE BINARY FRACTION OF DWARF M STARS [PDF]

, 2011
We describe a search for close spectroscopic dwarf M star binaries using data from the Sloan Digital Sky Survey to address the question of the rate of occurrence of multiplicity in M dwarfs.
B. M. Clark, C. Blake, G. Knapp
semanticscholar   +1 more source