Results 81 to 90 of about 3,567,567 (271)

Characterizing the visualization design space of distant and close reading of poetic rhythm. [PDF]

Front Big Data, 2023
Benito-Santos A, Muñoz S, Therón Sánchez R, García Peñalvo FJ.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Implementazione di scrittura riflessiva creativa e close reading nella rielaborazione dell’esperienza di tirocinio clinico per studenti di infermieristica: protocollo di studio multimetodo

Dissertation Nursing
Background: la formazione dei futuri professionisti sanitari influenza fortemente il loro sviluppo in termini di conoscenze, competenze e intelligenza emotiva.
Eleonora Zanella, Paola Arcadi, Carmela Santamaria, Stefano Terzoni, Maura Lusignani   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Vitality of Comparative Literature

Compendium
This essay deals with both the crisis of Comparative Literature and the aspects that should be considered in a renewed version of the discipline. In recent years, Comparative Literature has been struggling with newer disciplines, like Cultural Studies ...
Jan Baetens, Donata Meneghelli
doaj   +1 more source

Stasis in Moltmann e Schmitt

CoSMO, 2013
The essay introduces an original interpretation of Moltmann’s thought on Christian kenosis, according to the fundamental critical method known as ‘close reading’.
Pier Giuseppe Monateri
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A logical development: biomedicine's fingerprints are on the instrument of close reading in Charonian Narrative Medicine. [PDF]

Med Humanit, 2022
Neilson S.
europepmc   +1 more source

Close Reading and Truth

: Can statements of close reading be true? If so, what makes them true rather than false? If not, what is close reading doing? While the intuitive view might be that close reading is a truth-apt practice, this standard approach is flawed, and leads to ...
Sam Elgar
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source