Results 41 to 50 of about 11,686 (264)

Scenario-based designing of closed-loop supply chain with uncertainty in returned products [PDF]

Decision Science Letters, 2019
Closed-loop supply chain management is an effective and efficient solution for a set of activities to retrieve a product from a customer and improve its value or to dispose it.
Iman Ghasemian Sahebi, Behzad Masoom, Shahryar Ghorbani , Tanyeri Uslu   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Complaint management in closed-loop supply chain and performance evaluation by using exergoeconomics [PDF]

Journal of International Logistics and Trade, 2007
Complaint service management, aimed at improving customer satisfaction, provides important content for incorporation into studying a closed-loop supply chain.
Guojun Ji
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Decision making in fuzzy closed loop dual channel supply chain [PDF]

Yugoslav Journal of Operations Research
This paper discusses the optimal pricing and collecting decisions in a fuzzy environment of the three closed-loop dual-channel supply chain models where a manufacturer produces the original product from fresh materials and unfashionable products.
Mondal Animesh, Kumar Jana Ranjan, Kumar Jana Dipak   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Closed loop supply chain planning with vehicle routing

International Journal of Industrial Engineering and Production Research, 2016
In the recent decade, special attention is paid to reverse logistic due to economic benefits of recovery and recycling of used products as well as environmental legislation and social concerns. On the other hand، many researches claim that separately and
Mehrdad Mirzabaghi, Alireza Rashidi Komijan, Amir H. Sarfaraz   +2 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A novel approach integrating FANP and MOMILP for the collection centre location problem in closed-loop supply chain

International Journal of Sustainable Engineering, 2020
Supply chain network design plays a crucial role in supply chain management. With government support as well as restriction and legislation, the enhancement of environmental awareness, and the drive of economic interest, reverse logistics have been ...
Chuanrui Yang, Xiaohui Chen
doaj   +1 more source