Results 61 to 70 of about 4,393,220 (298)

Sustainable humanitarian operations: closed-loop supply chain [PDF]

International Journal of Services and Operations Management, 2016
This paper explores the closed loop supply chain (CLSC) topic by providing a model and evaluating regular humanitarian logistics (R-HL) where the main objective of the operation moves from the reduction of population needs to a minimisation of the overall impact of the disaster and operations.
BATTINI, DARIA, PERETTI, UMBERTO, PERSONA, ALESSANDRO, SGARBOSSA, FABIO   +3 more
openaire   +2 more sources

Co-Opetition Strategy for Remanufacturing the Closed-Loop Supply Chain Considering the Design for Remanufacturing

, 2022
The co-opetition strategy between manufacturers and remanufacturers is a key problem of the closed-loop supply chain, especially for the manufacturers often facing decision-making dilemmas when undertaking the environmental responsibilities of the design
Su, Zhang, Wang, Hu, Jian
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Closed-Loop Supply Chains in Circular Economy Business Models

, 2019
With the emergence of the circular economy (CE) approach into business models, there is need for deeper understanding of resource loops activities and how current supply chains can support the development of emerging CE business models. However, there is
Maria Holgado, Maria Holgado (4711419), Anna Aminoff, Anna Aminoff (16275167)   +3 more
core   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Special Section: Closed-Loop Supply Chains: Practice and Potential: The Challenge of Closed-Loop Supply Chains.

Interfaces, 2003
Closed-loop supply chains differ significantly from forward supply chains in many aspects. These differences are not well understood in many contexts, and the situation is complicated by many types of product returns. Progress is slow since closed-loop supply chains are rarely considered as value-creating systems, and much of the focus is on the ...
V. Daniel R. Guide Jr., Terry P. Harrison, Luk N. Van Wassenhove   +2 more
openaire   +2 more sources

A novel approach integrating FANP and MOMILP for the collection centre location problem in closed-loop supply chain

International Journal of Sustainable Engineering, 2020
Supply chain network design plays a crucial role in supply chain management. With government support as well as restriction and legislation, the enhancement of environmental awareness, and the drive of economic interest, reverse logistics have been ...
Chuanrui Yang, Xiaohui Chen
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Towards reducing electronic waste in a sustainable closed-loop supply chain [PDF]

Journal of Applied Research on Industrial Engineering
The increasing use of electronic goods worldwide has led to a significant increase in the amount of waste generated from their consumption, resulting in a primary environmental concern.
Pooria Malekinejad, Seyed Mirfakhradini, Ali Morovati Sharifabadi, Seyed Zanjirchi   +3 more
doaj   +1 more source