Results 61 to 70 of about 157,330 (294)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Design of an Improved Model for Anomaly Detection in CCTV Systems Using Multimodal Fusion and Attention-Based Networks

IEEE Access
Traditional approaches for video analysis often misdefine anomalies; they usually rely on single-modality input and have inadequate management of complex temporal patterns.
V. Srilakshmi, Sai Babu Veesam, Mallu Shiva Rama Krishna, Ravi Kumar Munaganuri, Dulam Devee Sivaprasad   +4 more
doaj   +1 more source

Graph-based discovery of ontology change patterns [PDF]

, 2011
Ontologies can support a variety of purposes, ranging from capturing conceptual knowledge to the organisation of digital content and information. However, information systems are always subject to change and ontology change management can pose challenges.
Abgaz, Yalemisew, Abgaz, Yalemisew Mintsnote, Pahl, Claus, Javed, Muhammad   +3 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Enhancing Vocabulary Acquisition and Language Learning Through Corpus Linguistic Approaches: The Role of Onomastics in Teaching Batik Madura’s Cultural Identity

Journal of Teaching and Learning
Research on corpus linguistics in language learning has primarily emphasized lexical patterns, collocations, and discourse structures, yet their application to onomastics remains underexplored.
Suhartatik, Wahyudi Siswanto, Roekhan
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

RT-Sort: An action potential propagation-based algorithm for real time spike detection and sorting with millisecond latencies.

PLoS ONE
With the use of high-density multi-electrode recording devices, electrophysiological signals resulting from action potentials of individual neurons can now be reliably detected on multiple adjacent recording electrodes.
Tjitse van der Molen, Max Lim, Julian Bartram, Zhuowei Cheng, Ash Robbins, David F Parks, Linda R Petzold, Andreas Hierlemann, David Haussler, Paul K Hansma, Kenneth R Tovar, Kenneth S Kosik   +11 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An integrated framework for memory-centric analysis: from trace collection to co-design

Frontiers in High Performance Computing
IntroductionThe memory wall phenomenon—where advances in processor performance significantly outpace those in memory subsystems-poses a fundamental challenge for contemporary computing systems.
Dhruv Gajaria, Prajwal Challa, Yasodha Suriyakumar, Joseph Manzano, Nathan Tallent, Andrés Márquez   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source