Results 51 to 60 of about 4,031,702 (245)

Greenhouse production analysis of early mission scenarios for Moon and Mars habitats

Open Agriculture, 2017
The establishment of planetary outposts and habitats on the Moon and Mars will help foster further exploration of the solar system. The crews that operate, live, and work in these artificial constructions will rely on bio-regenerative closed-loop systems
Schubert D.
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Hierarchies of Weighted Closed Partially-Ordered Patterns for Enhancing Sequential Data Analysis [PDF]

, 2017
International audienceDiscovering sequential patterns in sequence databases is an important data mining task. Recently, hierarchies of closed partially-ordered patterns (cpo-patterns), built directly using Relational Concept Analysis (RCA), have been ...
Cristina Nica, Agnès Braud, Braud, Agnès, Nica, Cristina, Florence Le Ber, Le Ber, Florence   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

CCPM: A Scalable and Noise-Resistant Closed Contiguous Sequential Patterns Mining Algorithm

, 2017
International audienceMining closed contiguous sequential patterns has been addressed in the literature only recently, through the CCSpan algorithm.
Brun, Armelle, Anne Boyer, Yacine Abboud, Abboud, Yacine, Boyer, Anne, Armelle Brun   +5 more
core   +1 more source

An integrated framework for memory-centric analysis: from trace collection to co-design

Frontiers in High Performance Computing
IntroductionThe memory wall phenomenon—where advances in processor performance significantly outpace those in memory subsystems-poses a fundamental challenge for contemporary computing systems.
Dhruv Gajaria, Prajwal Challa, Yasodha Suriyakumar, Joseph Manzano, Nathan Tallent, Andrés Márquez   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

An Efficient Chain Structure to Mine High-Utility Sequential Patterns

, 2019
High-utility sequential pattern mining (HUSPM) is an emerging topic in data mining, which considers both utility and sequence factors to derive the set of high-utility sequential patterns from the quantitative databases. Several works have been presented
Djenouri, Youcef, Philippe Fournier-Viger, Youcef Djenouri, Zhang, Ji, Yuanfa Li, Jerry Chun-Wei Lin, Lin, Jerry Chun-Wei, Li, Yuanfa, Ji Zhang, Fournier-Viger, Philippe   +9 more
core   +1 more source

A relevance criterion for sequential patterns

, 2022
S.369-384The theory of relevance is an approach for redundancy avoidance in labeled itemset mining. In this paper, we adapt this theory to the setting of sequential patterns.
Trabold, Daniel, Lang, B., Grosskreutz, Henrik   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source