Results 211 to 220 of about 7,966 (294)

Language-Invariant Strategies of Navigating Transitions in Joint Activities: Forms and Functions of Coordination Markers. [PDF]

Cogn Sci
Morozova N, Stoll S, Bangerter A.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Cryo-EM structure of the human THIK-1 K2P K⁺ channel reveals a lower Y gate regulated by lipids and anesthetics. [PDF]

Nat Struct Mol Biol
Rödström KEJ, Eymsh B, Proks P, Hayre MS, Cordeiro S, Mendez-Otalvaro E, Madry C, Rowland A, Kopec W, Newstead S, Baukrowitz T, Schewe M, Tucker SJ.   +12 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Thermally Activated Sliding of C₆₀ on Gold. [PDF]

ACS Omega
Pierno M, Bruschi L, Paolicelli G, di Bona A, Benedetti S, Manini N, Vanossi A, Mistura G.   +7 more
europepmc   +1 more source

CLOSED EXTREMALS

Proceedings of the National Academy of Sciences, 1929
openaire   +3 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Structural determinants for GqPCR-mediated inhibition of TASK K2P K ⁺ channels and their dysfunction in disease

Jouen-Tachoire TRH, Proks P, Seiferth D, Crowther K, Biggin PC, Baukrowitz T, Schewe M, Tucker SJ.   +7 more
europepmc   +1 more source

Unified characterization of the complete hierarchy of topological boundary states in a Floquet crystal. [PDF]

Natl Sci Rev
Guo Y, Lei Z, Wu J, Zhu J, Qin Y, Li L, Fan J.   +6 more
europepmc   +1 more source