Results 131 to 140 of about 40,986 (311)

Washed microbiota transplantation for Clostridioides difficile infection: A national multicenter real‐world study

Journal of Digestive Diseases, 2023
Fecal microbiota transplantation (FMT) has been recommended for the treatment of recurrent Clostridioides difficile infection (CDI). We aimed to evaluate the therapeutic efficacy and safety of washed microbiota transplantation (WMT), a new method of FMT,
Xia Wu, Rujun Ai, Jie Xu, Quan Wen, Huaqin Pan, Zhihua Zhang, Ning Wang, Ying Fang, Dafa Ding, Quan Wang, Shuang Han, Xiao Liu, Mei Wu, Zhenyu Jia, Jia Song, Tao Lin, Bota Cui, Y. Nie, Xin Wang, Faming Zhang   +19 more
semanticscholar   +1 more source

Epidemiology of Clostridioides difficile Infections in Germany, 2010–2019: A Review from Four Public Databases

Infectious Diseases and Therapy, 2023
Introduction Clostridioides difficile infection (CDI) is a recognized global threat especially for vulnerable populations. It is of particular concern to healthcare providers as it is found in both hospital and community settings, with severe courses ...
Gordon Brestrich, Frederick J. Angulo, Fabian K. Berger, Christian Brösamle, Stefan Hagel, Andreas Leischker, Christoph Lübbert, Friederike Maechler, Sophie-Susann Merbecks, Nadia Minarovic, Jennifer C. Moïsi, Lutz von Müller, Phillip A. Reuken, Thomas Weinke, Holly Yu, Alexander Mellmann   +15 more
doaj   +1 more source

Case Studies of Orphan Domain Reclassification in ECOD by Expert Curation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Homology‐based protein domain classification is a powerful tool for gaining biological insights into protein function. This classification process has been significantly enhanced by the availability of experimental structures and high‐accuracy structural models generated by advanced tools such as AlphaFold.
Jimin Pei, R. Dustin Schaeffer, Qian Cong, Nick V. Grishin   +3 more
wiley   +1 more source

Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection

Gut Pathogens, 2021
Background Clostridioides difficile infection (CDI) is an infectious nosocomial disease caused by Clostridioides difficile, an opportunistic pathogen that occurs in the intestine after extensive antibiotic regimens. Results Nine C.
Seung Woo Ahn, Se Hee Lee, Uh Jin Kim, Hee-Chang Jang, Hak-Jong Choi, Hyon E. Choy, Seung Ji Kang, Seong Woon Roh   +7 more
doaj   +1 more source

Gut Microbial Signatures Associated With Clinical Remission in Inflammatory Bowel Disease Treated With Biologics: A Comprehensive Multi‐Cohort Analysis

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims The relationship between gut microbiota and biological treatment response in inflammatory bowel disease (IBD) remains incompletely understood. We sought to characterize microbial signatures associated with clinical remission and develop a prediction model for clinical remission. Methods We analyzed 16 S rRNA gene sequencing
Qingyang Zheng, Yun Zhong, Haifeng Lian, Jieru Zhuang, Lichun Wang, Jianyong Chen, Huaiming Wang, Hui Wang, Xijie Ye, Zicheng Huang, Keli Yang   +10 more
wiley   +1 more source

Successful treatment of Pseudescherichia vulneris‐associated acute haemorrhagic diarrhoea with a single faecal microbiota transplantation in a dog

Veterinary Record Case Reports, EarlyView.
Abstract An 8‐year‐4‐month‐old, female, neutered labrador retriever with acute haemorrhagic diarrhoea was unresponsive to symptomatic and antibiotic treatment, and developed gastrointestinal protein loss leading to significant hypoalbuminaemia.
Luis Miguel Garcia Roldan, Glynn Woods, Julien Dandrieux, Silke Salavati Schmitz   +3 more
wiley   +1 more source

Management of Clostridioides difficile infection: an Italian Delphi consensus [PDF]

Background: Clostridioides difficile infection (CDI), a leading cause of nosocomial deaths, is a microbiota-mediated disease. As such, the use of broader spectrum antibiotics, such as vancomycin and metronidazole, can prime the gastrointestinal tract to ...
De Rosa, Francesco Giuseppe
core   +4 more sources

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses

MicrobiologyOpen, 2020
Clostridioides difficile infection (CDI) represents an important health problem worldwide, with significant morbidity and mortality. This infection has also high recurrence rates, whose pathophysiological grounds are still poorly understood. Based on our
Gabrio Bassotti, Andrea Marchegiani, Pierfrancesco Marconi, Katia Fettucciari   +3 more
doaj   +1 more source

Microbiological Foundations to Optimise Intrinsic Capacity and Promote Healthy Ageing: An Integration Into the Life Course Approach

Aging Cell, EarlyView.
Gut microbiota composition may influence trajectories of intrinsic capacity throughout life. Factors that positively or negatively impact gut microbiota (determining eubiosis or dysbiosis, respectively) can affect health, potentially acting through short‐chain fatty acids and their metabolic and anti‐inflammatory functions.
Christoph Benner, Matteo Cesari, Ritu Sadana   +2 more
wiley   +1 more source