Results 141 to 150 of about 25,400 (245)

Toxin production among epidemic Clostridioides difficile PCR ribotypes in Sweden

, 2020
Introduction Clostridioides difficile infection (CDI) is the main cause of antibiotic microflora triggered enteritis. Production of toxin A and B elicit enterocytic inflammation and diarrhea.
Berghamre, Hanna
core  

Clozapine‐induced diarrhea: A case report and mechanistic overview

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Clozapine is an atypical antipsychotic that is highly effective in managing treatment‐resistant schizophrenia. However, its use is associated with a wide range of adverse effects, including agranulocytosis, seizures, sedation, and gastrointestinal issues such as constipation, and less commonly, diarrhea. While constipation is a well‐
Shahab Dastmardi, Soha Namazi
wiley   +1 more source

Evaluating the Educational Value of Artificial Intelligence in Pharmacotherapy Education

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Final‐year medical students frequently make prescribing errors, partly because they have had insufficient training in therapeutic reasoning. Students need to understand the underlying rationale behind a drug choice in order to subsequently apply that knowledge critically and independently.
Mariëlle G. Hartjes, Michiel J. Bakkum, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar   +4 more
wiley   +1 more source

Contribution of MALDI‐TOF mass spectrometry and machine learning including deep learning techniques for the detection of virulence factors of Clostridioides difficile strains

Microbial Biotechnology
Clostridioides difficile (CD) infections are defined by toxins A (TcdA) and B (TcdB) along with the binary toxin (CDT). The emergence of the ‘hypervirulent’ (Hv) strain PR 027, along with PR 176 and 181, two decades ago, reshaped CD infection ...
Alexandre Godmer, Quentin Giai Gianetto, Killian Le Neindre, Valentine Latapy, Mathilda Bastide, Muriel Ehmig, Valérie Lalande, Nicolas Veziris, Alexandra Aubry, Frédéric Barbut, Catherine Eckert   +10 more
doaj   +1 more source

Proton Pump Inhibitors Prescribing Behaviors and Rationalization Strategies Among Healthcare Providers in Southeast Asia

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Long‐term proton pump inhibitor (PPI) therapy raises significant concerns regarding cost‐effectiveness and adverse effects, necessitating effective deprescribing strategies. An evaluation of 763 Southeast Asian healthcare providers revealed two distinct prescriber phenotypes, where a proactive cluster utilized diverse, guideline‐based rationalization ...
Duc Trong Quach, Tien Manh Huynh, Augusto Jose G. Galang, Hang Viet Dao, Sakkarin Chirapongsathorn, Phuripong Kijdamrongthum, Rahela Ambaras Khan, Andrew Ming‐Liang Ong, Wee Kooi Cheah, Kalwinder Singh Khaira, So Fie Tan, Jose Sollano, Ari Fahrial Syam, Tju Siang Chua, Somchai Leelakusolvong, Yeong Yeh Lee   +15 more
wiley   +1 more source

A Single Amino Acid Substitution in CspA Increases Germination Sensitivity and Broadens Bile Salt Germinant Specificity in Clostridioides difficile Spores

Environmental Microbiology, Volume 28, Issue 6, June 2026.
In reservoir‐associated RT033 strains, we observe a natural rewiring of spore germination that lowers the activation threshold and broadens bile‐salt specificity, enabling germination at low germinant levels and in response to typically inhibitory bile‐salts common in animal hosts.
Isabel Roseiro, Alexandra Nunes, Diogo Martins, Frederico Alves, Søren Persson, Adriano O. Henriques, Mónica Oleastro, Mónica Serrano   +7 more
wiley   +1 more source

Risk factors for further recurrences of Clostridioides difficile infection at the first and second recurrence: a retrospective cohort

BMC Infectious Diseases
Background Recurrent Clostridioides difficile infection is most effectively treated with faecal microbiota transplantation. Swedish and European guidelines suggest faecal microbiota transplantation after a first or second recurrence, respectively.
Måns Stefansson, Oscar Bladh, Piotr Nowak, Lars Rombo, Magnus Hedenstierna, Johan Ursing   +5 more
doaj   +1 more source

A Refined Method for Fecal Microbiota Transplantation Using Nutella

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Fecal microbiota transplantation (FMT) in mice is an evolving research field, often employing oral gavage, which can be stressful and harmful for the animals and time‐consuming for technicians. Voluntary intake methods, such as delivery in Nutella, have successfully been used for drug administration in mice and may likewise be a promising tool
Ida W. Henriksen, Camilla H. F. Hansen, Janne Koch, Dorte B. Sørensen, Dennis S. Nielsen, Christina Bartholdy, Axel K. Hansen   +6 more
wiley   +1 more source

Characterization of High-Linezolid-MIC Clostridioides difficile Isolated from a Chinese Hospital: First Genomic Evidence of Cfr(B) Transmission and Tn6218 Association

Xuyan Fu,1,* Xiajing Bi,2,* Tao Lv,1 Yunbo Chen1 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and ...
Bi X, Fu X, Lv T, Chen Y
core  

The Inflammatory Response in the Murine Ovalbumin‐Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Valid pre‐clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low‐to‐moderate inflammatory responses with significant variability, undermining their validity and contributing to high drug attrition rates.
Ida Wang Henriksen, Christina Bartholdy, Janne Koch, Denitsa Vladimirova Stefanova, Camilla Hartmann Friis Hansen, Axel Kornerup Hansen   +5 more
wiley   +1 more source