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Recommendations for the management of Clostridioides difficile infection in adults and comparison with updated ACG, ESCMID and IDSA/SHEA guidelines

Family Medicine & Primary Care Review
Clostridioides difficile infection is the most common cause of antibiotic-associated diarrhea. IDSA/SHEA, ESCMID and ACG updated the clinical practice guidelines for CDI in 2021. This paper is an attempt to summarize these guidelines.
Mateusz Piotr Baran, Jarosław Drobnik, Mária Belovičová, Štefánia Moricová, Piotr Pobrotyn   +4 more
doaj   +2 more sources

Clostridioides difficile co-infection with Enterohemorrhagic Escherichia coli (EHEC)—a potentially fatal combination

IDCases, 2020
There has been a significant increase in hospital and community acquired Clostridioides difficile infection in the past decade. In addition to CDI, the rate of infection with enterohemorrhagic Escherichia coli (EHEC) has also increased by 28% in United ...
Farah Deshmukh, Upasana Agrawal, Nancy Merrell   +2 more
doaj   +2 more sources

The Bacterial Gut Microbiota of Adult Patients Infected, Colonized or Noncolonized by Clostridioides difficile

Microorganisms, 2020
Gut microbiota composition in patients with Clostridioides difficile colonization is not well investigated. We aimed to identify bacterial signatures associated with resistance and susceptibility to C.
Monique J. T. Crobach, Quinten R. Ducarmon, Elisabeth M. Terveer, Celine Harmanus, Ingrid M. J. G. Sanders, Kees M. Verduin, Ed J. Kuijper, Romy D. Zwittink   +7 more
doaj   +1 more source

Reduction in Health Care Facility–Onset Clostridioides difficile Infection: A Quality Improvement Initiative

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2021
Objective: To reduce health care facility–onset (HCFO) Clostridioides difficile infection (CDI) incidence by improving diagnostic stewardship and reducing the inappropriate testing of C difficile assays.
Himesh B. Zaver, MD, Varun P. Moktan, MD, Eugene P. Harper, MD, Aman Bali, MD, Ayan Nasir, MD, Carla Foulks, MD, Justin Kuhlman, MD, Max Green, MD, Gillian A. Algan, BS, Heather C. Parth, MPH, Melody Wu-Ballis, BS, Sandra DiCicco, BS, Brenda T. Smith, BS, Ronald N. Owen, BS, Lorraine S. Mai, BS, Sarah L. Spiros, BS, John Griffis, BS, Daphne T. Ramsey Walker, BS, D. Jane Hata, PhD, Justin M. Oring, DO, Harry R. Powers, MD, Wendelyn Bosch, MD   +21 more
doaj   +1 more source

The analysis of the epidemic status and risk factors associated with different genotypes Clostridioides difficile mixed infection

BMC Microbiology
Background Clostridioides difficile is the main pathogen of antibiotic-associated diarrhea and pseudomembranous enteritis. Mixed Clostridioides difficile infection are simultaneous infection of the same host with strains of different genotypes. In recent
Yulian Zhang, Jing Yang, Honglian Wei, Jie Wang, Pu Qin, Qianqing Li, Cuixin Qiang, Jianhong Zhao   +7 more
doaj   +1 more source

Mortality Attributable to Clostridioides difficile Infection: The Rising Burden of Disease in European Countries

Medicina
Background and Objectives: Clostridioides difficile infection is a major public health issue, being among the main causes of mortality due to healthcare-associated diarrhea.
Irena Ilic, Ivana Zivanovic Macuzic, Milena Ilic   +2 more
doaj   +1 more source

Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany

Antimicrobial Resistance and Infection Control
Background Clostridioides difficile infections (CDI) present significant health risks and are among the most important nosocomial infections. Ribotype (RT) 027 poses a particular risk due to its proposed “hypervirulence”. Traditionally, C.
Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann, Mardjan Arvand   +9 more
doaj   +1 more source

Newer Therapeutics to Selectively Kill Clostridioides difficile and Restore the Microbiome

Infectious Disease Reports
Background: The antibiotic ibezapolstat and the live biotherapeutic product live-JSLM are promising future approaches for treating Clostridioides difficile infection.
Guido Granata, Nicola Petrosillo
doaj   +1 more source

Epidemiological characteristics of infections caused by bacteria Clostridioides difficile toxins [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. Clostridioides difficile is one of the most common infectious agents and an important cause of infections among hospitalized patients, often resulting in severe and potentially fatal outcomes.
Koprivica Marko, Đekić-Malbaša Jelena
doaj   +1 more source

Extraintestinal Clostridioides difficile Infection (CDI): A Recurrent Battle with Resilient Abdominal Wall Abscess

European Journal of Case Reports in Internal Medicine, 2023
Clostridioides (formerly Clostridium) difficile infection is a common and costly healthcare-associated infection. Extraintestinal C. difficile infection is rarely encountered, especially in isolation.
Justine Chinnappan, Murtaza Hussain, Dominic Awuah, Ekwevugbe Ogbon, Ghassan Bachuwa, Philip McDonald   +5 more
doaj   +1 more source