Results 11 to 20 of about 20,312 (245)

Mortality Attributable to Clostridioides difficile Infection: The Rising Burden of Disease in European Countries

Medicina
Background and Objectives: Clostridioides difficile infection is a major public health issue, being among the main causes of mortality due to healthcare-associated diarrhea.
Irena Ilic, Ivana Zivanovic Macuzic, Milena Ilic   +2 more
doaj   +2 more sources

Laboratory diagnostic methods for clostridioides difficile infection [PDF]

One Health & Risk Management, 2023
Introduction. Clostridioides difficile is an anaerobic gram-positive, sporeforming, toxin-producing bacillus that is transmitted among humans through the fecal-oral route, as a result of ingestion of spores. Colonization of C.
Anastasia ALEXANDROV
doaj   +1 more source

Incidence of hospital-acquired toxin-producing clostridioides difficile infection between the pre-pandemic (2017–2019) and pandemic (2020–2022): a retrospective cohort study [PDF]

Archives of Public Health
Background In 2020, the World Health Organization declared SARS-CoV-2 a global public health emergency. Healthcare systems were forced to reorganize care delivery and implement wide-ranging infection control strategies. Among hospital-acquired infections,
Raquel García Rodríguez, María José Pereira Rodríguez, Alejandra Pilar García López, Fabián Freijedo Fariñas, Angela Nogueira Gómez   +4 more
doaj   +2 more sources

Emerging Diagnostics in Clostridioides difficile Infection

International Journal of Molecular Sciences
Clostridioides difficile detection in community settings is time-intensive, resulting in delays in diagnosing and quarantining infected individuals. However, with the advent of semi-automated devices and improved algorithms in recent decades, the ability to discern CDI infection from asymptomatic carriage has significantly improved.
John P. Hulme
openaire   +3 more sources

The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses

MicrobiologyOpen, 2020
Clostridioides difficile infection (CDI) represents an important health problem worldwide, with significant morbidity and mortality. This infection has also high recurrence rates, whose pathophysiological grounds are still poorly understood. Based on our
Gabrio Bassotti, Andrea Marchegiani, Pierfrancesco Marconi, Katia Fettucciari   +3 more
doaj   +2 more sources

Editorial: Clostridioides difficile infection

Frontiers in Medicine
Guido Granata, Frédéric Barbut, Nicola Petrosillo   +2 more
doaj   +3 more sources

Clostridioides difficile infection: are the three currently used antibiotic treatment options equal from pharmacological and microbiological points of view?

International Journal of Infectious Diseases, 2022
Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI) have been updated. However, in addition to the clinical efficacy data, the drug of choice should ideally represent optimal antimicrobial stewardship, with an ...
Marcela Krutova, Mark Wilcox, Ed Kuijper
doaj   +1 more source

Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records

Frontiers in Immunology, 2021
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioides ...
Jiang Li, Yanfei Zhang, Alexandria L. Jilg, Donna M. Wolk, Harshit S. Khara, Amy Kolinovsky, David D. K. Rolston, Raquel Hontecillas, Josep Bassaganya-Riera, Marc S. Williams, Vida Abedi, Ming Ta Michael Lee   +11 more
doaj   +1 more source

Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study [PDF]

, 2021
Infecció per Clostridioides difficile; Mortalitat; Factors de riscInfección por Clostridioides difficile; Mortalidad; Factores de riesgoClostridioides difficile infection; Mortality; Risk factorsWe aimed to describe the clinical presentation, treatment ...
Mizrahi, Assaf, Khanafer, Nagham, Krutova, Marcela, Nuvials Casals, Xavier, Patyi, Márta, Czepiel, Jacek, Enoch, David A.   +6 more
core   +1 more source

IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection

Gut Microbes, 2021
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
doaj   +1 more source