Results 21 to 30 of about 1,730,491 (239)

Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records

Frontiers in Immunology, 2021
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioides ...
Jiang Li, Yanfei Zhang, Alexandria L. Jilg, Donna M. Wolk, Harshit S. Khara, Amy Kolinovsky, David D. K. Rolston, Raquel Hontecillas, Josep Bassaganya-Riera, Marc S. Williams, Vida Abedi, Ming Ta Michael Lee   +11 more
doaj   +1 more source

Development and characterisation of an in vitro human gut model to study the biofilm mode of growth of clostridium difficile and the indigenous gut microbiota [PDF]

, 2013
Clostridium difficile infection (CDI) is associated with significant patient morbidity, mortality and financial burden. Until recently, antimicrobial treatment options were limited to metronidazole and vancomycin, but both agents are associated with ...
Crowther, Grace
core   +6 more sources

Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection [PDF]

, 2023
Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood.
Seekatz, Anna M., Karen Wong, Tanya M. Monaghan, Dina Kao, Abbas Yadegar, Wong, Karen, Laura Cook, Walter, Jens, Ali Nabavi-Rad, Anna M. Seekatz, Kao, Dina, Monaghan, Tanya M., Cook, Laura, Jens Walter, Nabavi-Rad, Ali, Ibrahim, Fathima F., Pakpoor, Sepideh F., Sepideh Pakpoor, Fathima F. Ibrahim, Yadegar, Abbas   +19 more
core   +1 more source

IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection

Gut Microbes, 2021
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
doaj   +1 more source

Epidemiology of Clostridioides difficile Infection in Portugal: A Retrospective, Observational Study of Hospitalized Patients

Acta Médica Portuguesa, 2022
Introduction: Clostridioides difficile is the main cause of healthcare-associated diarrhea in Europe and North America. The aim of this study was to characterize the epidemiology and clinical burden of Clostridioides difficile infection among ...
Cláudia Nazareth, Inês Leitão, Ernestina Reis, Hugo Inácio, Filomena Martins, Elmano Ramalheira, Flávia Cunha, Carla Santos, Sara Lino, Hugo Moreira, Nadiya Kruptsala, Andrea Santos, Laura Paixão, Leonor Pássaro, Mónica Oleastro   +14 more
doaj   +1 more source

Clostridioides difficile Infection [PDF]

Annals of Internal Medicine, 2018
Clostridioides difficile (formerly Clostridium difficile) infection is the most frequently identified health care-associated infection in the United States. C difficile has also emerged as a cause of community-associated diarrhea, resulting in increased incidence of community-associated infection.
Alice Y, Guh, Preeta K, Kutty
openaire   +2 more sources

European Society of Clinical Microbiology and Infectious Diseases:2021 update on the treatment guidance document for Clostridioides difficile infection in adults [PDF]

, 2021
SCOPE: In 2009, the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) published the first treatment guidance document for Clostridioides difficile infection (CDI). This document was updated in 2014.
Guery, B., Wilcox, M.H., Hristea, A, Goorhuis, A, Tschudin-Sutter, S, Kuijper, E J, Coia, J; id_orcid, Bouza, E, van Rossen, T.M., Wilcox, M H, Allerberger, F, Vehreschild, M, Bouza, E., van Rossen, T M, Reigadas, E, van Prehn, J, Scharvik Olesen, B R, Norén, T., Allerberger, F., Ooijevaar, R.E., Scharvik Olesen, B.R., Burns, K, Ooijevaar, R E, van Prehn, J., Burns, K., Tschudin-Sutter, S., Krutova, M, Vogelzang, E.H., Hristea, A., Goorhuis, A., Fitzpatrick, F., Coia, J.E., Guery, B, Vehreschild, MJGT, Norén, T, Fitzpatrick, F, Krutova, M., Vogelzang, E H, Reigadas, E., Kuijper, E.J.   +39 more
core   +1 more source

Aerial dissemination of Clostridium difficile spores [PDF]

, 2008
YesClostridium difficile-associated diarrhoea (CDAD) is a frequently occurring healthcare-associated infection, which is responsible for significant morbidity and mortality amongst elderly patients in healthcare facilities. Environmental contamination is
Sleigh, P.A., Snelling, Anna M., Beggs, Clive B., Smith, Caroline F., Kerr, Kevin G., Banfield, Kathleen R., Roberts, K.   +6 more
core   +5 more sources

Update on Treatment of Clostridioides difficile Infection [PDF]

Mayo Clinic Proceedings, 2020
Clostridioides difficile infection (CDI) is the leading cause of health care-associated infections in the United States. The increasing incidence and recurrence rates of CDI together with its associated morbidity and mortality are great concerns.
Janice M. Cho, Darrell S. Pardi, Sahil Khanna   +2 more
openaire   +2 more sources

Does Fecal Microbiota Transplant Have a Role in Treating Recurrent Clostridioides difficile Infection in Rural Hospitals?

Frontiers in Public Health, 2021
Clostridioides difficile infection possesses a significant economical burden, specifically in the inpatient and rural settings. Fecal Microbiota Transplant has been used for treatment of recurrent Clostridioides difficile but its utility is limited by ...
Krishna Vedala, Philip Sobash, Parth Shah, Gilbert-Roy Kamoga   +3 more
doaj   +1 more source