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Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
doaj +1 more source
Clostridioides difficile is a Gram-positive anaerobic bacterium, which causes Clostridioides difficile infection (CDI). It has been recognised as a leading cause of healthcare-associated infections and a considerable threat to public health globally ...
Elaine Finn +2 more
semanticscholar +1 more source
Clostridioides difficile Infection [PDF]
Clostridioides difficile (formerly Clostridium difficile) infection is the most frequently identified health care-associated infection in the United States. C difficile has also emerged as a cause of community-associated diarrhea, resulting in increased incidence of community-associated infection.
Alice Y, Guh, Preeta K, Kutty
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Importance The effect of rationally defined nonpathogenic, nontoxigenic, commensal strains of Clostridia on prevention of Clostridioides difficile infection (CDI) is unknown.
T. Louie +14 more
semanticscholar +1 more source
Trends in U.S. Burden of Clostridioides difficile Infection and Outcomes.
BACKGROUND Efforts to prevent Clostridioides difficile infection continue to expand across the health care spectrum in the United States. Whether these efforts are reducing the national burden of C. difficile infection is unclear.
A. Guh +14 more
semanticscholar +1 more source
Persistent systemic microbial translocation, inflammation, and intestinal damage during Clostridioides difficile infection [PDF]
Background. Clostridioides difficile infection (CDI) might be complicated by the development of nosocomial bloodstream infection (n-BSI). Based on the hypothesis that alteration of the normal gut integrity is present during CDI, we evaluated markers of ...
Aversano, L. +13 more
core +1 more source
Porcine Colostrum Protects the IPEC-J2 Cells and Piglet Colon Epithelium against Clostridioides (syn. Clostridium) difficile Toxin-Induced Effects [PDF]
Clostridioides difficile toxins are one of the main causative agents for the clinical symptoms observed during C. difficile infection in piglets. Porcine milk has been shown to strengthen the epithelial barrier function in the piglet’s intestine and may ...
Grześkowiak, Łukasz +7 more
core +1 more source
Clostridioides difficile infection possesses a significant economical burden, specifically in the inpatient and rural settings. Fecal Microbiota Transplant has been used for treatment of recurrent Clostridioides difficile but its utility is limited by ...
Krishna Vedala +3 more
doaj +1 more source
Incidence and Outcomes Associated With Clostridium difficile Infections: A Systematic Review and Meta-analysis [PDF]
Importance: An understanding of the incidence and outcomes of Clostridium difficile infection (CDI) in the United States can inform investments in prevention and treatment interventions.
Balkenende, Erin +15 more
core +1 more source
ANTIDEPRESSANT MEDICATIONS ARE ASSOCIATED WITH INCREASED RISK OF HOSPITAL-ACQUIRED CLOSTRIDIOIDES DIFFICILE INFECTION: A POPULATION-BASED STUDY [PDF]
Background: During the past decade, Clostridioides difficile infection (CDI) has become the most common cause of antibiotic-associated diarrhea. Several risk factors have been implicated.
Antoine BOUSTANY +4 more
doaj +1 more source

