Results 161 to 170 of about 31,421 (293)

Optimization of synthetic human VH affinity and solubility through in vitro affinity maturation and minimal camelization

Protein Science, Volume 34, Issue 5, May 2025.
Abstract An attractive feature of human VHs over camelid VHHs as immunotherapeutics is their perceived lower risk of immunogenicity. While human VHs can readily be obtained from synthetic phage display libraries, they often suffer from low affinity and poor solubility compared to VHHs derived from immune libraries.
Kasandra Bélanger, Cunle Wu, Traian Sulea, Henk van Faassen, Deborah Callaghan, Annie Aubry, Marc Sasseville, Greg Hussack, Jamshid Tanha   +8 more
wiley   +1 more source

Bacteriophages Contribute to Shaping Clostridioides (Clostridium) difficile Species [PDF]

, 2018
Louis‐Charles Fortier
openalex   +1 more source

The Respiratory Tract Microbiome and Human Health

Microbial Biotechnology, Volume 18, Issue 5, May 2025.
The respiratory tract microbiome (RTM) trains the immune system and protects against infections. Changes in the RTM are linked to various respiratory diseases. High‐throughput methodologies and computational biology can improve our understanding of the RTM, paving the way for new diagnostic tools, treatments and preventive strategies to improve ...
Patricia Fernández de Córdoba‐Ansón, Iván Linares‐Ambohades, Fernando Baquero, Teresa M. Coque, Ana Elena Pérez‐Cobas   +4 more
wiley   +1 more source

Clostridioides difficile co-infection with Enterohemorrhagic Escherichia coli (EHEC)—a potentially fatal combination

IDCases, 2020
There has been a significant increase in hospital and community acquired Clostridioides difficile infection in the past decade. In addition to CDI, the rate of infection with enterohemorrhagic Escherichia coli (EHEC) has also increased by 28% in United ...
Farah Deshmukh, Upasana Agrawal, Nancy Merrell   +2 more
doaj  

Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018 [PDF]

, 2018
Harald Genth, Johannes Junemann, Chantal M. Lämmerhirt, Arlen-Celina Lücke, Ilona Schelle, Ingo Just, Ralf Gerhard, Andreas Pich   +7 more
openalex   +1 more source

Clinical and Microbiological Characteristics of Hospitalized Adults Aged ≤ 45 Years With Clostridioides (Formerly Clostridium) difficile Infection: A Prospective Observational Cohort Study From Hungary

APMIS, Volume 133, Issue 5, May 2025.
ABSTRACT Studies focusing on young adults with Clostridiodes (formerly Clostridium) difficile infection (CDI) are scarce. Our objective was to assess characteristics and outcomes of CDI among hospitalized young adults between the ages of 18–45 years at diagnosis, compared to a subcohort of randomly selected older patients aged > 45 years.
Borisz Rabán Petrik, Bálint Gergely Szabó, Boglárka Laky, Bence Marosi, Dorina Korózs, Csaba Lőrinczi, Katalin Fried, Botond Lakatos   +7 more
wiley   +1 more source

Retrospective Study of the Epidemiology of Clostridioides difficile Infection in the Neurosurgery Department of a Tertiary Hospital in China

Infection and Drug Resistance, 2023
Xiajing Bi,1 Lisi Zheng,2 Zhi Yang,1 Tao Lv,2 Xiaofei Tong,1 Yunbo Chen2,3 1Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2State Key Laboratory for Diagnosis and ...
Bi X, Zheng L, Yang Z, Lv T, Tong X, Chen Y   +5 more
doaj  

Cost Analysis of Computerized Clinical Decision Support and Trainee Financial Incentive for Clostridioides difficile Testing [PDF]

, 2018
Gregory R. Madden, Heather L. Cox, Melinda D. Poulter, Jason A. Lyman, Kyle B. Enfield, Costi D. Sifri   +5 more
openalex   +1 more source

Pseudothrombocytopenia due to Phagocytosis of Platelets by Polymorphonuclear Leukocytes

American Journal of Hematology, Volume 100, Issue 6, Page 1076-1077, June 2025.
Iliana Stamatiou, Zoe Bezirgiannidou, Evangelia Charitaki, Ioannis Kotsianidis, Konstantinos Liapis   +4 more
wiley   +1 more source

Antibiotic Use and Risk of Microscopic Colitis in Older Adults: A Nationwide Self‐Controlled Case Series Study

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 9, Page 1500-1507, May 2025.
In adults aged 65 and older, antibiotic use was linked to a higher risk of microscopic colitis. However, a negative control analysis suggests this association is likely due to detection bias during diagnostic workups, rather than a direct causal relationship.
Máté Szilcz, Jonas W. Wastesson, David Bergman, Kristina Johnell, Jonas F. Ludvigsson   +4 more
wiley   +1 more source