Results 141 to 150 of about 143,361 (253)

Nanjing Consensus II on Washed Microbiota Transplantation: Statements From the CHINAGUT Conference

Microbiota Medicine Research, Volume 1, Issue 2, Page 45-62, June 2026.
ABSTRACT The new method of fecal microbiota transplantation, based on automatic facilities and washing processes, was coined as washed microbiota transplantation (WMT). The first recommendations on WMT were released as Nanjing Consensus report by the fecal microbiota transplantation (FMT)‐standardization Study Group in 2019.
Faming Zhang, Sunny Hei Wong, Gaochen Lu, Zheshun Pi, Ting Zhang, Hon Ho Yu, Nan Bu, Xiong Chen, Bota Cui, Dafa Ding, Hainv Gao, Suyu He, Xingxiang He, Shengjuan Hu, Jia Hu, Yunlian Hu, Xiaomeng Jiang, Jiang Jin, Jingnan Li, Pan Li, Juan Liao, Weiwei Liao, Jiang Liu, Ling Liu, Yaping Liu, Yanyan Liu, Yu Liu, Muhan Lv, Xiangjun Meng, Yongzhan Nie, Qian Ren, Lixuan Sang, Yang Sun, Xiaowen Tang, Liangjing Wang, Wei Wang, Xin Wang, Yanling Wei, Quan Wen, Lihao Wu, Xia Wu, Fang Xiao, Lijing Xiong, Shaoqi Yang, Song Yang, Guoliang Ye, Yue Zeng, Huihong Zhai, Xiaoqian Zhang, Yu Zhang, Kun Zhao, Li Zhou, Li Zhu, Kaichun Wu   +53 more
wiley   +1 more source

Curbing inappropriate C. difficile treatment in patients receiving concomitant laxatives

Antimicrobial Stewardship & Healthcare Epidemiology
In the setting of universal Clostridioides difficile screening, we implemented an alert that triggered when C. difficile treatment was ordered in patients who recently received laxatives. This resulted in C.
Paige Fields, Christopher David, Anish Choksi, Natasha N. Pettit, Alison K. Lew, Jennifer Pisano, Cynthia T. Nguyen   +6 more
doaj   +1 more source

Antibacterial activity of ibezapolstat against antimicrobial-resistant clinical strains of Clostridioides difficile

Antimicrobial Agents and Chemotherapy
Antimicrobial resistance is emerging in clinical strains of Clostridioides difficile. Ibezapolstat (IBZ) is a DNA polymerase IIIC inhibitor that has completed phase II clinical trials.
E. Bassères, Taryn A. Eubank, K. Begum, M. J. Alam, Jin-Ung Jo, Thanh M Le, C. Lancaster, A. Gonzales-Luna, Kevin W. Garey   +8 more
semanticscholar   +1 more source

Risk factors for further recurrences of Clostridioides difficile infection at the first and second recurrence: a retrospective cohort

BMC Infectious Diseases
Background Recurrent Clostridioides difficile infection is most effectively treated with faecal microbiota transplantation. Swedish and European guidelines suggest faecal microbiota transplantation after a first or second recurrence, respectively.
Måns Stefansson, Oscar Bladh, Piotr Nowak, Lars Rombo, Magnus Hedenstierna, Johan Ursing   +5 more
doaj   +1 more source

De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants

Nature Communications
Clostridioides difficile toxin B (TcdB) is the key virulence factor accounting for C. difficile infection-associated symptoms. Effectively neutralizing different TcdB variants with a universal solution poses a significant challenge.
Xinchen Lv, Yuanyuan Zhang, Ke Sun, Qi Yang, Jianhua Luo, Liang Tao, Peilong Lu   +6 more
semanticscholar   +1 more source

Clozapine‐induced diarrhea: A case report and mechanistic overview

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Clozapine is an atypical antipsychotic that is highly effective in managing treatment‐resistant schizophrenia. However, its use is associated with a wide range of adverse effects, including agranulocytosis, seizures, sedation, and gastrointestinal issues such as constipation, and less commonly, diarrhea. While constipation is a well‐
Shahab Dastmardi, Soha Namazi
wiley   +1 more source

Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences

Journal of Antimicrobial Chemotherapy
Objectives To determine the frequencies and clonal distributions of putative genetic determinants of resistance to antimicrobials applied for treatment of Clostridioides difficile infection (CDI), as documented in the genomic record.
Baban Kolte, U. Nübel
semanticscholar   +1 more source

Evaluating the Educational Value of Artificial Intelligence in Pharmacotherapy Education

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Final‐year medical students frequently make prescribing errors, partly because they have had insufficient training in therapeutic reasoning. Students need to understand the underlying rationale behind a drug choice in order to subsequently apply that knowledge critically and independently.
Mariëlle G. Hartjes, Michiel J. Bakkum, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar   +4 more
wiley   +1 more source

A Review of Therapies for Clostridioides difficile Infection

Antibiotics
Clostridioides difficile is an urgent public health threat that affects approximately half a million patients annually in the United States. Despite concerted efforts aimed at the prevention of Clostridioides difficile infection (CDI), it remains a ...
Faiza Morado, Neha Nanda
doaj   +1 more source

Exogenous butyrate inhibits butyrogenic metabolism and alters virulence phenotypes in Clostridioides difficile

mBio
The gut microbiome engenders colonization resistance against the diarrheal pathogen Clostridioides difficile, but the molecular basis of this colonization resistance is incompletely understood.
D. Pensinger, Horia A. Dobrila, David M. Stevenson, Nicole D. Hryckowian, D. Amador-Noguez, A. J. Hryckowian   +5 more
semanticscholar   +1 more source