Results 121 to 130 of about 171,697 (237)

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source

N Engl J Med [PDF]

BACKGROUNDEfforts to prevent Clostridioides difficile infection continue to expand across the health care spectrum in the United States. Whether these efforts are reducing the national burden of C.

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Carbapenem Resistance in Clostridioides difficile [PDF]

, 2021
"Clostridioides difficile is a strict anaerobic, Gram-positive spore-forming bacterium and the leading cause of hospital acquired antibiotic associated diarrhoea. The development of antibiotic resistances by this bacterium is a serious threat.
Mendes, Aristides L.
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Evaluation of Clinical Practice Guidelines on Fecal Microbiota Transplantation in Adults: A Cross‐Sectional Study

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Objective Fecal microbiota transplantation (FMT) is an emerging multi‐disease therapy, yet the quality and consistency of its available clinical practice guidelines (CPGs) remain unknown. This study aimed to systematically evaluate the quality, content coverage and recommendation consistency of FMT‐related guidelines and develop an ...
Mingjuan Zhao, Shaojie Li, Guang Fu, Tong Deng, Yinghui Jin, Yingjiang Ye, Zhiqiang Li   +6 more
wiley   +1 more source

The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases

Journal of Periodontal Research, EarlyView.
This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

A Reassessment of Prophylactic Antibiotics in Low‐Infection‐Risk Electrophysiology Procedures

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Certain electrophysiology (EP) procedures are associated with minimal tissue disruption and do not involve permanent transvenous leads. As a result, these interventions carry a lower risk of device‐ or procedure‐related infection. These procedures include placement of implantable cardiac monitors, leadless pacemakers, and left atrial appendage
Rahel M. Sileshi, Katherine Mathes, Sathya Kosuri, Amulya Gupta, Neil Phillips, Rhea Pimentel, Martin Emert, Siva Soma, Rigoberto Ramirez, Raghuveer Dendi, Madhu Reddy, Seth H. Sheldon, Wissam El Atrouni, Larry M. Baddour, Amit Noheria   +14 more
wiley   +1 more source

Characterization of High-Linezolid-MIC Clostridioides difficile Isolated from a Chinese Hospital: First Genomic Evidence of Cfr(B) Transmission and Tn6218 Association [PDF]

Xuyan Fu,1,* Xiajing Bi,2,* Tao Lv,1 Yunbo Chen1 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and ...
Bi X, Fu X, Lv T, Chen Y
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Clinical Significance of Organ Preservation Fluid Cultures in Pediatric Abdominal Solid Organ Transplantation

Transplant Infectious Disease, EarlyView.
In this pediatric abdominal solid organ transplant cohort, preservation fluid‐related infections were rare but occurred in infant liver transplant recipients whose preservation fluid cultures grew pathogenic organisms. These findings suggest that routine bacterial preservation fluid cultures may be most useful for identifying clinically significant ...
Hassan A. Jamal, Yong K. Kwon, Pamela L. Valentino, Jodi M. Smith, Patrick J. Healey, Zheyi Teoh   +5 more
wiley   +1 more source

The Direction of the Clostridioides difficile–Gastrointestinal GVHD Relationship After Allogenic Hematopoietic Cell Transplantation: A Time‐Dependent CIBMTR Analysis

Transplant Infectious Disease, EarlyView.
In 7175 allogeneic transplant recipients, gastrointestinal graft‐versus‐host disease increased the risk of subsequent Clostridioides difficile infection, but CDI did not predict later GVHD. The direction emerged only when timing was respected; an apparent PTCy association disappeared once CDI diagnosed before the drug was given was excluded.
Aseel H. Alzibdeh, Ahmed Zaqout, Samar Hashim, Maha AlJabri, Suleiman AbuJarir, Mohammad Bakir, Muna AlMaslamani, Ali S. Omrani   +7 more
wiley   +1 more source