Results 101 to 110 of about 171,697 (237)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Quantification of Clostridioides (Clostridium) difficile in feces of calves of different age and determination of predominant Clostridioides difficile ribotype 033 relatedness and transmission between family dairy farms using multilocus variable-number tandem-repeat analysis

open access: yesBMC Veterinary Research, 2018
Background Community acquired Clostridioides (Clostridium) difficile infection (CA-CDI) is a significant health problem in human and veterinary medicine. Animals are often considered as potential reservoirs for CA-CDI.
Petra Bandelj   +6 more
doaj   +1 more source

Association of enteral nutrition reduction or discontinuation with diarrhea volume and caloric delivery in critically ill adults with diarrhea: A retrospective cohort study

open access: yesNutrition in Clinical Practice, EarlyView.
Abstract Background When critically ill patients receiving enteral nutrition (EN) develop diarrhea, clinicians often reduce or discontinue EN, although evidence supporting this practice is limited. We examined the association between EN management after diarrhea and diarrhea volume in critical care patients.
Ryohei Yamamoto   +4 more
wiley   +1 more source

Clostridioides difficile infection presenting as ileus [PDF]

open access: yes, 2022
Clostridioides difficile (previously, Clostridium difficile) is a frequent cause of hospital-acquired diarrhoea and has shown a rising trend in community-acquired infections as well, with widespread use of antibiotics, among other risk factors.
Nikhil Bhangale
core  

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

open access: yesSmall, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li   +4 more
wiley   +1 more source

Clostridioides difficile in chicken fresh meat at retail in France

open access: yes
International audienceFoodborne transmission of Clostridioides difficile is strongly suspected, particularly through poultry fresh meat products. In this study, C. difficile was detected in 1.5% of chicken thighs (n = 271) but in none of the cutlets (n = 
Reboul, Guillaume   +7 more
core   +1 more source

Microbiome Insights Into Zoonotic Risk at Wildlife–Human Interfaces in a Transitioning Landscape in Thailand

open access: yesIntegrative Zoology, EarlyView.
This study shows how ecological transitions, such as reforestation in Southeast Asia, reshape host–microbe–pathogen dynamics at the wildlife–domestic interface. By integrating long‐read microbiome sequencing, ecological gradients, and statistical and network analysis, we identify host species that disproportionately contribute to pathogen diversity and
Pauline Van Leeuwen   +9 more
wiley   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

open access: yesJournal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes   +2 more
wiley   +1 more source

Clostridioides difficile infection: an update

open access: yesInfezioni in Medicina
Clostridioides difficile (C. difficile) is a Gram-positive, spore-forming anaerobic bacterium emerged as a leading cause of diarrhea globally. CDI's (Clostridioides difficile infection) impact on healthcare systems is concerning due to high treatment cost and increased hospitalisation time.
Federica, Salvati   +4 more
openaire   +2 more sources

Hospital Infection Control: Clostridioides difficile.

open access: yes, 2020
Clostridioides difficile remains a leading cause of healthcare-associated infection. Efforts at C. difficile prevention have been hampered by an increasingly complex understanding of transmission patterns and a high degree of heterogeneity among existing
Anderson, Deverick J, Turner, Nicholas A
core   +1 more source

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