Results 81 to 90 of about 168,874 (243)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Microbiota Transplantation Effectively Treats Immune Checkpoint Inhibitor‐Associated Colitis: A Multi‐Center, Retrospective Case Series

Microbiota Medicine Research, EarlyView.
ABSTRACT Background Immune‐mediated colitis is an adverse effect of therapy with immune checkpoint inhibitors (ICIs). This study aims to evaluate the efficacy and safety of washed microbiota transplantation (WMT) in patients with ICI‐associated colitis.
Mengyu Huang, Yaping Liu, Hong Lu, Weihong Wang, Huiying Gao, Junlan Qiu, Yan Jin, Qian Ren   +7 more
wiley   +1 more source

Clostridioides difficile

Acta Médica Grupo Ángeles, 2023
Thomas J. Sandora, Larry K. Kociolek
  +5 more sources

Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients

, 2023
Funding: This study was funded by Fondo de Investigaciones Sanitarias (FIS), Research Project number PI16/00490 and PI20/01381, PFIS grant number FI21/00310, and by the European Regional Development Fund (FEDER) “A way of making Europe”.Introduction ...
Vázquez Cuesta, Silvia, Bouza Santiago, Emilio, Villar, Laura, García Lozano, Nuria, Alcalá, Luis, Fernández, Ana I., Muñoz García, Patricia Carmen, Reigadas Ramírez, Elena Manuela, Olmedo, María, Marín Arriaza, María De Las Mercedes   +9 more
core   +1 more source

Case report of two patients with recurrent watery stools following prophylactic ileostomy reversal after rectal cancer surgery

结直肠肛门外科
The causes of diarrhea after enterostomy reversal may be related to surgical treatment, and its severity varies. Clinical interventions are often based on the patient’s symptomatic presentation.
Shen Shuai, Gao Hui
doaj   +1 more source

Современные подходы к иммунотерапии инфекции Clostridioides difficile [PDF]

Clostridioides difficile is a leading cause of diarrhea and pseudomembranous colitis associated with antibiotic therapy. Hypervirulent strains of C. difficile, such as ribotype 027, have high mortality rates. Recurrent C. difficile infection is extremely
V. V. Makarov, К. Э. Попруга, K. E. Popruga, В. В. Макаров   +3 more
core   +1 more source

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

Small, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li, Jiaxuan Xiao, Jimmy Gu, Zhen Zhang, Yingfu Li   +4 more
wiley   +1 more source

Microbiome Insights Into Zoonotic Risk at Wildlife–Human Interfaces in a Transitioning Landscape in Thailand

Integrative Zoology, EarlyView.
This study shows how ecological transitions, such as reforestation in Southeast Asia, reshape host–microbe–pathogen dynamics at the wildlife–domestic interface. By integrating long‐read microbiome sequencing, ecological gradients, and statistical and network analysis, we identify host species that disproportionately contribute to pathogen diversity and
Pauline Van Leeuwen, Chuanpot Thinphovong, Vincent Sluydts, Alix Nicolas, Anamika Kritiyakan, Areeya Kriengudom, Pipat Soisook, Kittipong Chaisiri, Serge Morand, Johan Michaux   +9 more
wiley   +1 more source

Proteomic antibacterial characterization of flavonoid xanthohumol and probiotic Clostridium butyricum on pathogenic Clostridioides difficile

Chinese Medicine
Background The management of dysbiotic gut microbiota in Clostridioides difficile infection has attracted increasing scholarly attention. The development of therapeutic agents with low toxicity, derived from both the flavonoid xanthohumol and the short ...
Shenkun Wei, Guorong Li, Qiong Yang, Xinping Zhu, Junjie Liang, Mengyi Liu, Zijian Chen, Xia Liu, Jun-Yu Xu, Wei Chen   +9 more
doaj   +1 more source

Antimicrobial resistance surveillance of Clostridioides difficile in Australia, 2015-18

, 2021
Background: Clostridioides difficile was listed as an urgent antimicrobial resistance (AMR) threat in a report by the CDC in 2019. AMR drives the evolution of C. difficile and facilitates its emergence and spread. The C.
Hemphill, C, Putsathit, P, McGlinchey, A, Moore, CV, Kotsanas, D, McDougall, R, Robson, J, Hong, S, Huntington, PG, Lahra, M, George, N, Prendergast, L, Nimmo, GR, et al., Korman, TM   +14 more
core   +1 more source