A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]
, 2020 Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan +4 more
core
Some simple rules for estimating reproduction numbers in the presence of reservoir exposure or imported cases [PDF]
arXiv, 2018 The basic reproduction number ($R_0$) is a threshold parameter for disease extinction or survival in isolated populations. However no human population is fully isolated from other human or animal populations. We use compartmental models to derive simple rules for the basic reproduction number for populations with local person-to-person transmission and
arxiv
Journal of Biological Chemistry, 2013 Background: Botulinum HA is a component of the botulinum neurotoxin complex and dramatically increases the oral toxicity of the complex. Results: The crystal structure of botulinum HA reveals that 12 subcomponents of HA constitute a huge triskelion ...
S. Amatsu +4 more
semanticscholar +1 more source
Application of PCR to a clinical and environmental investigation of a case of equine botulism [PDF]
, 1994 PCR for the detection of botulinum neurotoxin gene types A to E was used in the investigation of a case of equine botulism. Samples from a foal diagnosed with toxicoinfectious botulism in 1985 were reanalyzed by PCR and the mouse bioassay in conjunction ...
Desmarchelier P.M. +5 more
core +1 more source
Infant botulism in Costa Rica: first report from Central America
Journal of Infection in Developing Countries, 2014 Introduction: Clostridium botulinum is known to cause descending paralysis in infants throughout the world. Methodology: The subject of this study was a three-month-old Costa Rican boy who was hospitalized because of poor suction and feeding, hypotonia,
Marcela Hernandez-de Mezerville +4 more
doaj +1 more source
An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production [PDF]
, 2016 Clostridium botulinum produces botulinum neurotoxins (BoNTs), highly potent substances responsible for botulism. Currently, mathematical models of C.
Barker, Gary C. +4 more
core +2 more sources
A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]
, 2008 Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Bal Ram Singh +6 more
core +1 more source
Effect of Sodium Chloride and pH on the Outgrowth of Spores of Type E Clostridium botulinum at Optimal and Suboptimal Temperatures1 [PDF]
, 1966 W. P. Segner, C. F. Schmidt, J. K. Boltz
openalex +2 more sources
Ciência Rural, 2008 Botulismo é uma intoxicação causada pela ingestão das toxinas produzidas pelo Clostridium botulinum, que acomete mamíferos e aves, caracterizando-se por um quadro de paralisia flácida. Neste trabalho, é descrito um caso de botulismo em ganso, ocorrido no
Francisco Carlos Faria Lobato +7 more
doaj +1 more source
The Utilization of Amino Acids and of Glucose by Clostridium botulinum [PDF]
, 1940 Charles Clifton
openalex +1 more source