Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application
Exploration, EarlyView.This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang +4 more
wiley +1 more source
Clostridium difficile and the microbiota [PDF]
Journal of Clinical Investigation, 2014 Clostridium difficile infection (CDI) is the leading health care-associated illness. Both human and animal models have demonstrated the importance of the gut microbiota's capability of providing colonization resistance against C. difficile. Risk factors for disease development include antibiotic use, which disrupts the gut microbiota, leading to the ...
Vincent B. Young, Anna M. Seekatz
openaire +2 more sources
A review on the effects of probiotics and antibiotics towards Clostridium difficile infections [PDF]
, 2013 Clostridium difficile can cause severe diseases with significant morbidity and mortality in infected patients. The rate of Clostridium difficile infection is high in North America and European countries. Metronidazole and vancomycin have been recommended
Abd Manap, Mohd Yazid +4 more
core
Molecular epidemiology of endemic Clostridium difficile infection [PDF]
, 2001 This is the first study to provide a comprehensive insight into the molecular epidemiology of endemic Clostridium difficile and particularly that associated with a recently recognized epidemic strain. We DNA fingerprinted all C.
Fawley, W.N., Wilcox, M.H.
core +2 more sources
Presence and molecular characterization of Clostridium difficile and Clostridium perfringens in intestinal compartments of healthy horses [PDF]
, 2012 BACKGROUND: Clostridium difficile and Clostridium perfringens are commonly associated with colitis in equids, but healthy carriers exist. Scarce information is available on the prevalence of Clostridium spp.
Angelika Schoster +4 more
core +2 more sources
Confidence bounds for the sensitivity lack of a less specific diagnostic test, without gold standard [PDF]
arXiv, 2010 We consider the problem of comparing two diagnostic tests based on a sample of paired test results without true state determinations, in cases where the second test can reasonably be assumed to be at least as specific as the first. For such cases, we provide two informative confidence bounds: A lower one for the prevalence times the sensitivity gain of
arxiv
Biological Journal of Microorganism, 2014 Introduction: With regard to increasing of community associated Clostridium difficile infection in recent years, the probable transmission of Clostridium difficile from food to human was supposed.
zahra Esfandiari +4 more
doaj
In vitro activities of MCB3681 and 8 comparators against Clostridium difficile isolates with known ribotypes and diverse geographical spread [PDF]
, 2017 Treatments for Clostridium difficile infection remain limited, despite the introduction of fidaxomicin, and development of new agents is necessary.
Freeman, J +3 more
core +1 more source
Some simple rules for estimating reproduction numbers in the presence of reservoir exposure or imported cases [PDF]
arXiv, 2018 The basic reproduction number ($R_0$) is a threshold parameter for disease extinction or survival in isolated populations. However no human population is fully isolated from other human or animal populations. We use compartmental models to derive simple rules for the basic reproduction number for populations with local person-to-person transmission and
arxiv
Investigation of the Cyprus donkey milk bacterial diversity by 16SrDNA high-throughput sequencing in a Cyprus donkey farm [PDF]
arXiv, 2020 The interest in milk originating from donkeys is growing worldwide due to its claimed functional and nutritional properties, especially for sensitive population groups, such as infants with cow milk protein allergy. The current study aimed to assess the microbiological quality of donkey milk produced in a donkey farm in Cyprus using cultured-based and ...
arxiv