Results 111 to 120 of about 277,449 (338)

Laboratory data as a quality indicator of health-care-associated infections in England. [PDF]

open access: yes, 2018
Routine diagnostic laboratory results, e.g. numbers of meticillin-resistant Staphylococcus aureus (MRSA) bacteraemias, have been used as health-care-associated infection quality indicators for decades. The English health-care-associated infection quality
Jeyaratnam, D, Planche, T
core   +1 more source

Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse Model

open access: yesMsphere, 2018
Clostridium difficile is a bacterial pathogen of global significance that is a major cause of antibiotic-associated diarrhea. Antibiotics deplete the indigenous gut microbiota and change the metabolic environment in the gut to one favoring C.
J. R. Fletcher   +3 more
semanticscholar   +1 more source

Whole microbiota transplantation restores gut homeostasis throughout the gastrointestinal tract

open access: yesiMeta, EarlyView.
This study introduces whole microbiota transplantation (WMT), a synergistic therapeutic approach that concurrently transplants small intestinal and fecal microbiota. In germ‐free mice, WMT outperforms conventional fecal microbiota transplantation (FMT) in restoring gut microbiota diversity and abundance.
Bufu Tang   +8 more
wiley   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou   +6 more
wiley   +1 more source

Dietary trehalose enhances virulence of epidemic Clostridium difficile

open access: yesNature, 2017
Clostridium difficile disease has recently increased to become a dominant nosocomial pathogen in North America and Europe, although little is known about what has driven this emergence.
James Collins   +7 more
semanticscholar   +1 more source

Isolated gastrointestinal Langerhans cell histiocytosis in a 16‐month‐old child: A case report

open access: yesJPGN Reports, EarlyView.
Abstract Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells, most often involving the skin or bone. Isolated gastrointestinal (GI) involvement is extremely uncommon in young children. We report a 16‐month‐old girl with a 1‐month history of chronic vomiting, bloody diarrhea, and failure to ...
Al‐Qasim AL‐Bahlani   +3 more
wiley   +1 more source

Clostridium difficile on YouTube: A need for greater focus on prevention

open access: yesJournal of Infection and Public Health, 2018
The purpose of this study was to describe the content of the most popular YouTube videos related to Clostridium difficile. Across all sources, the kinds of content most likely to be included in the videos was general information, overuse of antibiotics ...
Corey H. Basch   +3 more
doaj   +1 more source

Extraintestinal Clostridioides difficile infection

open access: yesIDCases, 2020
Clostridioides (Clostridium) difficile is the major cause of healthcare antibiotic-associated diarrhoea. However, extra-intestinal manifestations of Clostridioides (Clostridium) difficile infection (CDI) (including bacteremia and tissue infection) are ...
Zhao Hai   +6 more
doaj   +1 more source

The effects of storage conditions on viability of Clostridium difficile vegetative cells and spores and toxin activity in human faeces [PDF]

open access: yes, 2003
AIMS: Clostridium difficile is a common nosocomial pathogen and as such diagnostic and research methods may necessitate storage of faecal specimens for long periods, followed by subsequent re-examination.
Freeman, J., Wilcox, M.H.
core   +1 more source

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]

open access: yes, 2020
Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan   +4 more
core  

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