Results 141 to 150 of about 277,449 (338)

Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections

Frontiers in Microbiology, 2018
Fecal microbiota transplantation has proven to be an effective treatment for infections with the gram-positive enteropathogen Clostridium difficile. Despite its effectiveness, the exact mechanisms that underlie its success are largely unclear.
A. Baktash, E. Terveer, R. Zwittink, B. Hornung, J. Corver, E. Kuijper, W. K. Smits   +6 more
semanticscholar   +1 more source

Cryptococcid Sweet Syndrome in the Setting of Hydralazine‐Induced ANCA Vasculitis: A Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Acute febrile neutrophilic dermatosis, also known as Sweet syndrome, is an inflammatory skin condition characterized by the rapid onset of painful, erythematous plaques or nodules with neutrophilic infiltrate on histology. Rarely, acellular bodies surrounded by vacuolated spaces have been noted within the neutrophilic infiltrate, mimicking ...
Jenna Vroman, Pelin Sagut, Kathryn Lynam, Amanda Ederle, Laura Winterfield   +4 more
wiley   +1 more source

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).

Clinical Infectious Diseases, 2018
L. C. Mcdonald, D. Gerding, Stuart Johnson, J. Bakken, Karen C. Carroll, Susan E. Coffin, E. Dubberke, K. Garey, Carolyn V Gould, C. Kelly, V. Loo, Julia Shaklee Sammons, Thomas J. Sandora, Mark H. Wilcox   +13 more
semanticscholar   +2 more sources

Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience [PDF]

, 2018
Yao‐Wen Cheng, Emmalee Phelps, Vincent Ganapini, Noor Ul Ain Khan, Fangqian Ouyang, Huiping Xu, Sahil Khanna, Raseen Tariq, Rachel Friedman‐Moraco, Michael H. Woodworth, Tanvi Dhere, Colleen S. Kraft, Dina Kao, Justin Smith, Lien Le, Najwa El‐Nachef, Nirmal Kaur, Sree Kowsika, Adam C. Ehrlich, Michael S. Smith, Nasia Safdar, Elizabeth Ann Misch, Jessica R. Allegretti, Ann D. Flynn, Zain Kassam, Asif Sharfuddin, Raj Vuppalanchi, Monika Fischer   +27 more
openalex   +1 more source

A novel kirkovirus may be associated with equine gastrointestinal disease

Equine Veterinary Journal, EarlyView.
Abstract Background Many cases of equine enterocolitis are suspected to be infectious in nature, but no pathogen is identified in many cases. Objectives Perform next‐generation sequencing on faeces collected from cases of equine enterocolitis for the presence of novel viruses and determine if an identified novel virus is associated with cases of equine
Lillian M. B. Haywood, Ava Clark, Ben Hause, Breanna Sheahan   +3 more
wiley   +1 more source

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Nature Communications, 2018
Clostridium difficile is the leading cause of pseudomembranous colitis in hospitalized patients. C. difficile enterotoxins TcdA and TcdB promote this inflammatory condition via a cytotoxic response on intestinal epithelial cells (IECs), but the ...
Pedro H. V. Saavedra, Linyan Huang, Farzaneh Ghazavi, S. Kourula, T. Vanden Berghe, N. Takahashi, P. Vandenabeele, M. Lamkanfi   +7 more
semanticscholar   +1 more source

Safety of Potassium‐Competitive Acid Blockers Compared With Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease and Peptic Ulcer Disease: A Systematic Review and Meta‐Analysis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Potassium‐competitive acid blockers (P‐CABs) are a novel class of acid suppressants developed to overcome the limitations of proton pump inhibitors (PPIs), providing rapid and sustained acid suppression. While PPI‐related adverse events (AEs) are well‐documented, safety data on P‐CABs remain limited.
Yewon Jang, Jongho Park, Dahee Kang, Jae Hyun Kim, Hyuk Soon Choi, Ha‐Lim Jeon, Hankil Lee   +6 more
wiley   +1 more source

Pharmacokinetics of surotomycin from phase 1 single and multiple ascending dose studies in healthy volunteers

BMC Pharmacology and Toxicology, 2017
Background Surotomycin, a novel, orally administered, cyclic, lipopeptide antibacterial in development for the treatment of Clostridium difficile-associated diarrhea, has demonstrated minimal intestinal absorption in animal models.
Gurudatt Chandorkar, Qiao Zhan, Julie Donovan, Shruta Rege, Hernando Patino   +4 more
doaj   +1 more source

Mecillinam: a low-risk antimicrobial agent for induction of Clostridium difficile infection in an in vitro human gut model [PDF]

, 2009
Simon D. Baines, Rory J O’Connor, G. S. Huscroft, Katherine Saxton, Jane Freeman, Mark H. Wilcox   +5 more
openalex   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source