Results 51 to 60 of about 1,784,951 (230)

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores. [PDF]

, 2013
Clostridium difficile is the leading cause of hospital acquired diarrhoea in industrialised countries. Under conditions that are not favourable for growth, the pathogen produces metabolically dormant endospores via asymmetric cell division.
Fairweather, NF, Fairweather Neil F., Richard A. Stabler (179807), Wren, Brendan W, Neil F Fairweather, Adam A. Witney (230772), Dembek, Marcin, Marcin Dembek (124261), Stabler Richard A., Fairweather, Neil F, Richard A Stabler, Stabler, Richard A, Wren, BW, Witney Adam A., Witney, AA, Witney, Adam A, Marcin Dembek, Wren Brendan W., Stabler, RA, Dembek Marcin, Brendan W. Wren (114209), Dembek, M, Adam A Witney, Neil F. Fairweather (224028), Brendan W Wren   +24 more
core   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Emergence and global spread of epidemic healthcare-associated clostridium difficile [PDF]

, 2012
Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary history leading to its emergence and the subsequent patterns of global ...
Hawkey, P.r, Brazier, Jon, Martin, Melissa J, Fairley, Derek, Brown, D., Kim, H.J., Kuijper, Ed, Kato, Haru, Coia, JE, Kathleen B Bamford, Tse Hsien Koh, Kim, HJ, He, M., Wren, B.W., Miyajima, Fabio, Riley, Tom, Brazier, J. S., Kato, H., Harris, Simon R, D'Arc, S., Butt, E., Nick M Brown, Gerding, D, Martin, M.J., Wren, BW, Paul Roberts, Douce, G, Pirmohamed, M, Munir Pirmohamed, Louise Ellison, Songer, Glen, Songer, G, Coia, John E., He, M, Brendan W Wren, Douce, Gill, Kuijper, E., Sharon J Peacock, Pickard, Derek J, Butt, Emma, Mark Wilcox, Lawley, Trevor D, Dale Gerding, Wren, Brendan W, Songer, G., Senoh, Mitsutoshi, Haru Kato, Mitsutoshi Senoh, D'Arc, S, Hee Jung Kim, Pirmohamed, M., Connor, Thomas Richard, Ellison, Louise, Brown, Nick M, Wilcox, Mark, Miyajima, F, Pickard, Derek J., Harris, S.R., Roberts, Paul, Koh, Tse Hsien, Melissa J Martin, Julian Parkhill, Hawkey, P., Louie, T., Bamford, KB, Coia, J., Dougan, Gordon, Coia, John E, Parkhill, Julian, Hawkey, P, Ed Kuijper, Bamford, Kathleen B., Thomas R Connor, Gill Douce, Glen Songer, Pickard, D.J., Simon R Harris, Tom Louie, Derek Fairley, Fairley, D, Miyajima, F., Wilcox, M, Parkhill, J, Michell, S., Tom Riley, Louie, Tom, Harris, Simon R., Louie, T, Lawley, T.D., Bamford, K.B., He, Miao, Gerding, Dale, Connor, T.R., Peacock, Sharon J., Kuijper, E, Butt, E, Peacock, SJ, Brown, Derek, Senoh, M., Gordon Dougan, Pirmohamed, Munir, Gerding, D., Ellison, L, Peter Hawkey, Koh, T.H., Harris, SR, Brazier, J., Wilcox, M., Trevor D Lawley, Coia, J.E., Emma Butt, Ellison, L., Peacock, Sharon J, Brown, NM, Michell, S, Derek Brown, Derek J Pickard, Brown, Nick M., 김희정, Martin, MJ, Peacock, S.J., Brown, N.M., Dougan, G., Brown, D, Riley, T., Kim, Hee Jung, Brazier, J, Kato, H, Connor, Thomas R, Fairley, D., Parkhill, J., Stephanie D'Arc, Wren, Brendan W., D'Arc, Stephanie, Douce, G., Lawley, TD, John E Coia, Fabio Miyajima, Michell, Stephen, Jon Brazier, Lawley, Trevor D., Martin, Melissa J., Miao He, Stephen Michell, Roberts, P., Koh, TH, Hawkey, Peter, Pickard, DJ, Bamford, Kathleen B, Douce, G.l, Roberts, P, Riley, T, Connor, TR, Senoh, M, Dougan, G   +154 more
core   +1 more source

A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients

Guoji laonian yixue zazhi
[Objective] To investigate the risk factors of Clostridium difficile infection in elderly inpatients and provide the theoretical basis for the prevention and treatment of Clostridium difficile infection.
Yang Chen, Yingjun Gong, Cui Li, Huan Li, Jia Chen, Hui Su, Xiaoming Wang, Xiaoxuan Ning   +7 more
doaj   +1 more source

Targeting B‐Cell‐Activating Factor and Its Receptor in Immune Thrombocytopenia and Warm Autoimmune Hemolytic Anemia

American Journal of Hematology, EarlyView.
ABSTRACT Current treatments for immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA), rare autoimmune diseases in which autoreactive B cells play a major role, can lead to high response rates; however, for many patients these responses are not durable or maintained after treatment discontinuation.
Matthieu Mahévas, Nichola Cooper, Vickie McDonald, Karina Yazdanbakhsh, Wilma Barcellini   +4 more
wiley   +1 more source

Modern Recent on the Laboratory Diagnosis of Clostridium Difficile-associated Infection

Журнал инфектологии, 2014
In the review the current information on the laboratory diagnosis of Clostridium difficile-associated infection. Made a critical assessment of the effectiveness and specificity of the modern methods of diagnosis: methods of isolation and identification ...
A. S. Kvet naya,, P. S. Makridi, M. K. Behtereva   +2 more
doaj   +1 more source

High Clostridium difficile Infection among HIV-Infected Children with Diarrhea in a Tertiary Hospital in Mwanza, Tanzania

International Journal of Pediatrics, 2020
Clostridium difficile causes a million of illnesses each year worldwide and can affect people of all ages. Limited data exist on the prevalence of C. difficile infections (CDI) among children below five years of age in developing countries. This study is
Mwanaisha Seugendo, Aldofine Hokororo, Rogatus Kabyemera, Delfina R. Msanga, Mariam M. Mirambo, Vitus Silago, Uwe Groß, Stephen E. Mshana   +7 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage. [PDF]

, 2011
Clostridium difficile is the most common cause of antibiotic-associated diarrhoea worldwide. Over the past 10 years, the incidence and severity of disease have increased in North America and Europe due to the emergence of a hypervirulent clone designated
Valiente, Esmeralda, Michelle D. Cairns, Brendan W. Wren, Dawson, Lisa F, Stabler, Richard A, Cairns, Michelle D, Wren, Brendan W, Esmeralda Valiente, Richard A. Stabler, Lisa F. Dawson   +9 more
core   +1 more source