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In recent years, the number of infectious diseases caused by Clostridium difficile in the world has grown with a significant increase in relapses and mortality in patients, particularly among cancer patients in hospitals.
Mariya G. Shvydkaya +2 more
doaj +1 more source
Clostridium difficile Infection [PDF]
Preventing Clostridium difficile, the most common cause of health care–associated infections in hospitals and infectious disease death in the United States, is a national priority. Increased rates of infection among low-risk individuals in the community call for community-based prevention efforts to halt the increasing spread of this highly contagious ...
Jennan A, Phillips, Stephanie, Hammond
openaire +2 more sources
Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
Maria Scarselli (247406) +39 more
core +1 more source
Introduction: The infection with Clostridium difficile has increased in incidence worldwide and it raises many problems with regard to therapy, resistance to treatment and especially recurrence.
Mihaela Laszlo +3 more
doaj +1 more source
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. [PDF]
Relapsing C. difficile disease in humans is linked to a pathological imbalance within the intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that mice infected with epidemic C.
Parkhill Julian +94 more
core +1 more source
The Issue of Early Diagnosis of Intestinal Complications at Antibiotic Therapy in Children
The objective of the research was to improve the timely diagnosis of intestinal complications of antibiotic therapy, caused by Clostridium difficile infection in children.
O.A. Radutna +3 more
doaj +1 more source
Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores. [PDF]
Clostridium difficile is the leading cause of hospital acquired diarrhoea in industrialised countries. Under conditions that are not favourable for growth, the pathogen produces metabolically dormant endospores via asymmetric cell division.
Fairweather, NF +24 more
core +1 more source
Clostridium difficile infection: review [PDF]
Clostridium difficile (C. difficile) is a Gram-positive, spore-forming, anaerobic bacillus, which is widely distributed in the intestinal tract of humans and animals and in the environment. In the last decade, the frequency and severity of C. difficile infection has been increasing worldwide to become one of the most common hospital-acquired infections.
Jacek Czepiel +9 more
openaire +6 more sources
F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu +5 more
wiley +1 more source
The aim of this meta-analysis was to compare the efficacy of metronidazole and vancomycin for the treatment of Clostridium difficile infection, especially to investigate which agent was superior for treating either mild or severe C.
Xiuzhen Di +9 more
doaj +1 more source

