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Clostridium difficile Infection
Critical Reviews in Clinical Laboratory Sciences, 1996The spore-forming anaerobe Clostridium difficile has become a serious enteropathogen. Changes in the composition of natural intestinal flora, mainly due to antibiotic therapy, permit its colonization of, and multiplication in, the colon. The disease is caused by (entero)toxin A and (cyto)toxin B, and infection ranges from asymptomatic carrier state and
Dieter H. M. Gröschel, B. Toye
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CLOSTRIDIUM SORDELLI INFECTION
The Journal of Trauma: Injury, Infection, and Critical Care, 1975A case of human Clostridium sordelli soft tissue infection is presented. Analysis of this patient's course led to the use of a mouse experimental model for examination of this organism's potential for toxin production. Data thus obtained correlated with that seen in this instance of human infection, indicates that the lethal effects of this organism ...
John H. Davis +4 more
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CNS Infection with Clostridium septicum
Scandinavian Journal of Infectious Diseases, 2000We present an unusual case of Clostridium septicum brain infection in a 72-yr-old woman who had no underlying malignant disease. The infection spread from a localized sit to the CNS causing gas formation. The patient died rapidly.
Dirks, C. +3 more
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Clostridium septicum Infections and Malignancy
JAMA: The Journal of the American Medical Association, 1969Twenty-eight patients had infections due to Clostridium septicum ; 21 of them had documented septicemia. A malignancy was present in 23 of the 27 patients for whom hospital records were available. In three, an intestinal tumor was found one to two months after C septicum was cultured.
Robert J. Alpern, V. R. Dowell
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Clostridium difficile Infection
Annual Review of Medicine, 1998Clostridium difficile infection is associated with broad-spectrum antibiotic therapy and is the most common cause of infectious diarrhea in hospital patients. Pathogenic strains of C. difficile produce two protein exotoxins, toxin A and toxin B, which cause colonic mucosal injury and inflammation. Infection may be asymptomatic, cause mild diarrhea, or
Ciaran P. Kelly, J T LaMont
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Clostridium difficile infection.
BMJ (Clinical research ed.), 2009Rangaiah and colleagues comment that currently used tests for Clostridium difficile toxin are not very sensitive.1 However, the specificity of these commercial assays also ranges from 97% to 99%, meaning that approximately 1-2 out of every 10 positive results using these kits are incorrect.2 False positive results are even more likely when testing ...
Tim Planche, Mark H. Wilcox
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Clostridium perfringens and foodborne infections
International Journal of Food Microbiology, 2002Clostridium perfringens type A food poisoning is one of the more common in the industrialised world. This bacterium is also responsible for the rare but severe food borne necrotic enteritis. C. perfringens enterotoxin (CPE) has been shown to be the virulence factor responsible for causing the symptoms of C. perfringens type A food poisoning.
Per Einar Granum, Sigrid Brynestad
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Clostridium Difficile Infection [PDF]
, 2018 Clostridium difficile colitis occurs as a chronic or an acute illness with intensity varying from mild to severe. The surgeon will most often encounter this disease in the acute setting and will need to recognize how to properly assess the patient and when to intervene surgically.
Nandini Shetty, Alicia Yeap
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Update on Clostridium difficile infections
Médecine et Maladies Infectieuses, 2014Clostridium difficile infections (CDI) occur primarily in hospitalized patients with risk factors such as concomitant or recent use of antibiotics. CDI related additional costs are important for the global population and health-care facilities. CDI epidemiology has changed since 2003: they became more frequent boosted by large outbreaks, more severe ...
Frédéric Barbut +2 more
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Treatment of Clostridium difficile Infections
Infectious Disease Clinics of North America, 2015Vancomycin and metronidazole were historically considered equivalent therapies for the management of Clostridium difficile infections (CDI); however, recent data confirm more favorable outcomes with vancomycin. Fidaxomicin is a narrow spectrum antibiotic that has an advantage in reducing recurrence rates compared with vancomycin, possibly owing to its ...
Stuart Johnson, Melinda M. Soriano
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