Results 71 to 80 of about 111,997 (256)

Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia

British Journal of Pharmacology, Volume 182, Issue 18, Page 4400-4418, September 2025.
Abstract Background and Purpose Local inhibitory circuits and long‐range inhibitory projections within the interconnected basal ganglia nuclei are critical for control of voluntary movement and pathophysiology of different extrapyramidal movement disorders.
Patrik Meglić, Petra Šoštarić, Davor Virag, Ana Knezović, Nikola Habek, Ornella Rossetto, Ivica Matak   +6 more
wiley   +1 more source

Seroprevalence of Clostridium tetani in Donkeys in Kaduna State, Nigeria

, 2020
Tetanus is an acute non-contagious and infectious disease caused by Clostridium tetani exotoxins that affect many animal species and humans. It is associated with high mortality rate, ranging from 58% to 80% in Equidae.
O. Emmanuel, Shuiabu Mohammed, A. Mordecai, Alimi Abdulrasheed, U. Deborah   +4 more
semanticscholar   +1 more source

The Microbiota‐Gut‐Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
The microbiota‐gut‐brain axis (MGBA) is a crucial regulator of neurological and neuropsychiatric disorders, with gut microbiota dysbiosis linked to various diseases. Gut microbiota changes can lead to neurodegenerative diseases like depression, autism, schizophrenia, Parkinson's, Alzheimer's, dementia, multiple sclerosis, epilepsy, anxiety, and autism ...
Md. Faysal, Mehrukh Zehravi, Baishakhi Sutradhar, Md Al Amin, Thukani Sathanantham Shanmugarajan, Uppuluri Varuna Naga Venkata Arjun, Susithra Ethiraj, Akiladevi Durairaj, Girija Dayalan, Shaik Khadeer Ahamad, Safia Obaidur Rab, Kannan Raman, Talha Bin Emran   +12 more
wiley   +1 more source

Electroencephalography of rapid eye movement sleep behavior disorder in a dog with generalized tetanus

Journal of Veterinary Internal Medicine, 2023
Case Summary A 3‐month‐old Airedale dog with clinically diagnosed generalized tetanus was investigated for the occurrence of excessive paddling and chewing movements when sleeping.
Marguerite Knipe, Colleen Embersics, Peter Dickinson   +2 more
doaj   +1 more source

Clostridium tetani infection in pediatric intensive care unit of the CHU of Tamatave Madagascar

Pediatric Review: International Journal of Pediatric Research, 2020
Justification: Tetanus, fatal disease, still exists in Madagascar in spite of the vaccination sessions of mass, and attacks also the children. Objective: To describe the epidemiology, the clinical aspect, the treatments and the evolutions of infantile ...
A. Ratsimbazafy, A. Andrianarivelo, M. Rakotomahefa, S. T. Rakotoarivony, H. Rakotoarisoa, Jean De La Croix Rasolonjatovo   +5 more
semanticscholar   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, Volume 5, Issue 4, August 2025.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Tetanus in a Non-Immunized Adult: Early Diagnosis and Successful Management - A Case Report

National Journal of Medical Research
Introduction Tetanus is an acute infectious disease of the nervous system caused by Clostridium tetani (C. tetani) characterized by muscle spasms that are caused by the toxin-producing spores of the anaerobic bacteria.
Monesh Verma, Gourav Patidar, Garima Namdev   +2 more
doaj   +1 more source

Dental Caries as a Risk Factor of Tetanus [PDF]

, 2014
Tetanus is an acute toxemia caused by neurotoxins of Clostridium tetani with characterized periodic and severe muscle spasms. Clostridium tetani spores usually enter the body through the skin due to wounds , dental caries, punctured or burns as well as ...
Harum, A. (Aroma)
core  

Botulinum Neurotoxins: History, Mechanism, and Applications. A Narrative Review

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Botulinum neurotoxins (BoNTs), produced by Clostridium botulinum, bind irreversibly to presynaptic cholinergic nerve terminals and exploit a zinc‐dependent mechanism to cleave SNARE proteins, blocking acetylcholine release and causing flaccid paralysis.
Arik Monash, Joseph Tam, Osnat Rosen, Hermona Soreq   +3 more
wiley   +1 more source

Disruption of salt bridge interactions in the inter‐domain cleft of the tubulin‐like protein FtsZ of Escherichia coli makes cells sensitive to the cell division inhibitor PC190723

Cytoskeleton, Volume 82, Issue 7, Page 415-431, July 2025.
Abstract FtsZ forms a ring‐like assembly at the site of division in bacteria. It is the first protein involved in the formation of the divisome complex to split the cell into two halves, indicating its importance in bacterial cell division. FtsZ is an attractive target for developing new anti‐microbial drugs to overcome the challenges of antibiotic ...
Sakshi Mahesh Poddar, Joyeeta Chakraborty, Pananghat Gayathri, Ramanujam Srinivasan   +3 more
wiley   +1 more source