Results 121 to 130 of about 957,959 (360)
Closure systems and closure hypergroups
Ratio Mathematica, 1999 Given a closure system, a hyperoperation is defined by setting as hyperproduct of two elements the minimum element containing them. Some properties on the topic are proved, and the concept of a closure hypergroup is defined.
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
THE OXIDATION OF 3-(N-BENZYLACETAMIDO)-1,2-PROPANEDIOL TO N-BENZYLACETAMIDOACETALDEHYDE AND RING CLOSURE OF THE LATTER TO ISOQUINOLINEL [PDF]
, 1955 Arlen W. Frank, C. B. Purves
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Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
The Journal of Hebrew Scriptures, 2011 In recent decades several scholars have argued for the coherence of Judges 13–16 based on its multiple internal thematic and structural parallels. Yet previous generations of scholars considered Judges 13–16 to be a loose cycle of stories. Exploration of the narrative’s closural mechanisms suggests two primary reasons that the episodes strike readers ...
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Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Turbulence Closure With Small, Local Neural Networks: Forced Two‐Dimensional and β‐Plane Flows
Journal of Advances in Modeling Earth SystemsWe parameterize sub‐grid scale (SGS) fluxes in sinusoidally forced two‐dimensional turbulence on the β‐plane at high Reynolds numbers (Re ∼25,000) using simple 2‐layer convolutional neural networks (CNN) having only O(1000) parameters, two orders of ...
Kaushik Srinivasan +2 more
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
STUDIES OF THE PULMONARY AND SYSTEMIC ARTERIAL PRESSURE IN CASES OF PATENT DUCTUS ARTERIOSUS WITH SPECIAL REFERENCE TO EFFECTS OF SURGICAL CLOSURE 1 [PDF]
, 1950 Bowen E. Taylor +4 more
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Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
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