Results 121 to 130 of about 1,865,587 (341)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Closures and topological closures in quasi-discrete closure spaces

open access: yesApplied Mathematics Letters, 2010
First for a finite set \(U\) and then an infinite set \(U\), the author establishes a one to one correspondence between the quasi-discrete closures on \(U\) and the reflexive relations on \(U\) and shows that \(S\) is the transitive closure of \(R\) if \(R\) and \(S\) are the relations determined by the closures cl and \(\text{cl}_T\) (the topological ...
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Trumpets as Odd Ending or Fitting Closure?

open access: yesOld Testament Essays
The instruction for trumpets (Num 10:1-10) is the final unit of the text viewed by the majority of scholars as the opening major section of Numbers (1:1-10:10).
Janson Condren
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The Good Place, ou ce que les séries se doivent les unes aux autres

open access: yesTV Series
This article on The Good Place (NBC, 2016-2020) explores the series’ reflexivity and meta-discourse on contemporary seriality, by comparing it to other metatextual TV series with similar themes.
Florent Favard
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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