Results 61 to 70 of about 907,349 (311)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Ranks for Families of Theories of Abelian Groups
Известия Иркутского государственного университета: Серия "Математика", 2019 The rank for families of theories is similar to Morley rank and can be considered as a measure for complexity or richness of these families. Increasing the rank by extensions of families we produce more rich families and obtaining families with the ...
In. I. Pavlyuk, S.V. Sudoplatov
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
On the Independence Number of Traceable 2-Connected Claw-Free Graphs
Discussiones Mathematicae Graph Theory, 2019 A well-known theorem by Chvátal-Erdőos [A note on Hamilton circuits, Discrete Math. 2 (1972) 111–135] states that if the independence number of a graph G is at most its connectivity plus one, then G is traceable.
Wang Shipeng, Xiong Liming
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Turbulence Closure With Small, Local Neural Networks: Forced Two‐Dimensional and β‐Plane Flows
Journal of Advances in Modeling Earth SystemsWe parameterize sub‐grid scale (SGS) fluxes in sinusoidally forced two‐dimensional turbulence on the β‐plane at high Reynolds numbers (Re ∼25,000) using simple 2‐layer convolutional neural networks (CNN) having only O(1000) parameters, two orders of ...
Kaushik Srinivasan +2 more
doaj +1 more source
Stroke: Vascular and Interventional NeurologyBackground Patent foramen ovale (PFO) contributes to a quarter of embolic strokes of undetermined source. Although the benefit of PFO closure in selected patients has been demonstrated, our system workflow still resulted in a low rate of PFO evaluation ...
Yasaman Pirahanchi +14 more
doaj +1 more source