Results 131 to 140 of about 787,356 (301)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
On regular and homological closure operators [PDF]
, 2009 Observing that weak heredity of regular closure operators in Top and of homological closure operators in homological categories identifies torsion theories, we study these closure operators in parallel, showing that regular closure operators play the ...
Clementino, Maria Manuel +1 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Ninth Illinois Custom Spray Operators' Training School: Summaries of presentations
, 1957 Illinois Custom Spray Operators' School Summaries of Presentations. January 24-25, 1957. In cooperation with University of Illinois College of Agriculture, Agricultural Extension Service, and the Illinois Natural History Survey.
Illinois Custom Spray Operators' School
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Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Generalized Open Sets and Closure Operators via Point-to-Neighborhood Assignments
MathematicsWe equip a topological space (X,τ) with a function a:X→τ satisfying the single axiom x∈a(x). The resulting triple (X,τ,a), which we call an aura topological space, provides a point-to-open-set assignment that differs from all existing auxiliary ...
Ahu Açıkgöz
doaj +1 more source
Eighteenth Illinois Custom Spray Operators' Training School: summaries of presentations [PDF]
, 1966 Made available in DSpace on 2016-03-17T21:24:38Z (GMT). No. of bitstreams: 2 7912186_1966.pdf: 13598820 bytes, checksum: db1fa5d0d5989386ccddb7340b143729 (MD5) license.txt: 4846 bytes, checksum: 927d59ba442de31571446841df3d90ca (MD5) Previous issue ...
Illinois Custom Spray Operators' School
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source