Results 121 to 130 of about 16,063 (299)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
On regular and homological closure operators
, 2010 Observing that weak heredity of regular closure operators in Top and of homological closure operators in homological categories identifies torsion theories, we study these closure operators in parallel, showing that regular closure operators play the ...
Clementino, Maria Manuel +1 more
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Fuzzy closure operators with truth stressers,
, 2005 We study closure operators and closure structures in a fuzzy setting. Our main interest is the monotony condition of closure operators. In a fuzzy setting, the monotony condition may take several particular forms, all of them equivalent in the bivalent ...
Radim Bělohlávek, Vilém Vychodil
core
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Pawlak Algebra and Approximate Structure on Fuzzy Lattice
The Scientific World Journal, 2014 The aim of this paper is to investigate the general approximation structure, weak approximation operators, and Pawlak algebra in the framework of fuzzy lattice, lattice topology, and auxiliary ordering.
Ying Zhuang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Path-induced closure operators on graphs for defining digital Jordan surfaces
Open Mathematics, 2019 Given a simple graph with the vertex set X, we discuss a closure operator on X induced by a set of paths with identical lengths in the graph. We introduce a certain set of paths of the same length in the 2-adjacency graph on the digital line ℤ and ...
Šlapal Josef
doaj +1 more source