Results 51 to 60 of about 525,933 (279)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An integrable multicomponent quad equation and its Lagrangian formulation

, 2012
We present a hierarchy of discrete systems whose first members are the lattice modified Korteweg-de Vries equation, and the lattice modified Boussinesq equation. The N-th member in the hierarchy is an N-component system defined on an elementary plaquette
A. I. Bobenko, D.-J. Zhang, F. W. Nijhoff, F. W. Nijhoff, F. W. Nijhoff, F. W. Nijhoff, F. W. Nijhoff, G. R. W. Quispel, I. M. Gel’fand, J. Atkinson, J. Atkinson, J. Atkinson, J. Hietarinta, L. Bianchi, L. Lewin, P. J. McCarthy, P. Xenitidis, P. Xenitidis, R. Hirota, R. Hirota, S. B. Lobb, S. B. Lobb, S. B. Lobb, S. B. Lobb, S. Yoo-Kong, V. E. Adler, Yu. I. Manin   +26 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A Toy Model for Torsorial Nature of Representations

Information, 2012
This paper presents a toy model for the representation related phenomena. It is the representation that is always referred to. The represented thing in itself is indeterminate existence at a fundamental level of understanding.
Makoto Yoshitake
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Remarks on the range and the kernel of generalized derivation

Математичні Студії, 2022
Let $L(H)$ denote the algebra of operators on a complex infinite dimensional Hilbert space $H$ and let $\;\mathcal{J}$ denote a two-sided ideal in $L(H)$. Given $A,B\in L(H)$, define the generalized derivation $\delta_{A,B}$ as an operator on $L(H)$ by
Y. Bouhafsi, M. Ech-chad, M. Missouri, A. Zouaki   +3 more
doaj   +1 more source

Modal logic of planar polygons [PDF]

, 2018
We study the modal logic of the closure algebra $P_2$, generated by the set of all polygons in the Euclidean plane $\mathbb{R}^2$. We show that this logic is finitely axiomatizable, is complete with respect to the class of frames we call "crown" frames ...
Gabelaia, David, Gogoladze, Kristina, Jibladze, Mamuka, Kuznetsov, Evgeny, Marx, Maarten   +4 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source