Results 61 to 70 of about 14,588,697 (257)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Blood group distribution and its association with bleeding time and clotting time among medical students

Asian Journal of Medical Sciences
Background: Blood group, bleeding time (BT), and clotting time (CT) are routinely performed tests in the hospital, especially before any surgeries and blood transfusion.
Bijaya Adhikari , Niroj Maharjan
doaj   +1 more source

Gender - Does it affect BT (Bleeding Time) or CT (Clotting Time): A cross sectional study in medical students [PDF]

Al Ameen Journal of Medical Sciences, 2016
Background: Bleeding time (BT) and Clotting time (CT) assess the integrity of haemostatic mechanisms. Haemostasis is the arrest of bleeding. Bleeding time depends on the effectiveness of vasoconstriction as well as platelet plug formation, while Clotting
Monika Gavali, Yogesh Gavali, Samir Singru, Krishnakant Patil   +3 more
doaj  

Correlation of bleeding time and clotting time in different phases of menstrual cycle

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: Changes in the levels of female sex hormones during the menstrual cycle are known to affect the coagulation cascade by producing parallel changes in the prothrombotic tendency and the fibrinolytic activity of healthy women.
Shivani Prajapati, Ritu Adhana, Anjali Verma   +2 more
doaj   +1 more source

Global cerebral infarction after aortic arch replacement surgery in a patient with postoperatively revealed factor XII deficiency: a case report

Journal of Medical Case Reports, 2020
Background This case report presents a case of a patient with global cerebral infarction of uncertain etiology following an emergency surgery for acute type A aortic dissection. As a result, factor XII deficiency was revealed postoperatively.
Keisuke Yoshida, Shiori Tanaka, Yuki Sato, Kazuhiro Watanabe, Kenichi Muramatsu, Masahiro Murakawa   +5 more
doaj   +1 more source

Selective light-triggered release of DNA from gold nanorods switches blood clotting on and off. [PDF]

PLoS ONE, 2013
Blood clotting is a precise cascade engineered to form a clot with temporal and spatial control. Current control of blood clotting is achieved predominantly by anticoagulants and thus inherently one-sided.
Helena de Puig, Anna Cifuentes Rius, Dorma Flemister, Salmaan H Baxamusa, Kimberly Hamad-Schifferli   +4 more
doaj   +1 more source

Pengaruh Pemberian Single Clove Black Garlic terhadap Lamanya Clotting Time dan Bleeding Time pada Tikus dengan Induksi Streptozotocin [PDF]

, 2020
Latar Belakang: Diabetes melitus merupakan penyakit yang dapat mengakibatkan disfungsi endotel sehingga meningkatkan terjadinya komplikasi aterotrombotik. Single clove black garlic dapat menurunkan risiko komplikasi aterotrombotik.
ANISA, Sahra
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Trypsin is as procoagulant as factor XIIa

Bleeding, Thrombosis and Vascular Biology
To help shed light on the roles of the contact pathway of blood clotting, we quantified the relative procoagulant activities of each of the serine proteases of the clotting cascade.
Stephanie A. Smith, James H. Morrissey
doaj   +1 more source