Results 191 to 200 of about 76,424 (294)

Physiologically‐Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT A physiologically‐based pharmacokinetic (PBPK) model of niraparib and its primary metabolite using a relevant virtual cancer population is reported here. A series of in vitro experiments using liver S9, microsomes, and hepatocytes with various inhibitors and recombinant supersomes demonstrated that niraparib is specifically metabolized by ...
Gareth J. Lewis, Roxanne C. Jewell, Anu Shilpa Krishnatry, Kunal S. Taskar   +3 more
wiley   +1 more source

Relationship Between Clozapine-Induced Inflammation and Eosinophilia: A Retrospective Cohort Study. [PDF]

Schizophr Bull
Kikuchi Y, Otsuka Y, Ito F, Yada Y, Tanifuji H, Komatsu H, Tomita H.   +6 more
europepmc   +1 more source

Delay in Clozapine Initiation in Patients with Treatment-Resistance  Schizophrenia Presenting Tertiary Psychiatric Facilities

Asad Ullah Jan, Sajid Rahim
openalex   +2 more sources

Interoceptive Information of Physical Vigor Through Circulating Insulin‐Like Growth Factor 1

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
Schematic representation of the relationships between circulating IGF‐1, orexin, and VTA neurons to promote physical activity. After physical activity is increased in response to internal or external stimuli, entrance of circulating IGF‐1 into the brain is enhanced (1).
Jonathan A. Zegarra‐Valdivia, M. Zahid Khan, Jansen Fernandes, Kentaro Suda, M. Estrella Fernandez de Sevilla, Sonia Díaz‐Pacheco, Ignacio Torres Aleman   +6 more
wiley   +1 more source

Management of Parkinson's disease psychosis-a European perspective. [PDF]

Lancet Reg Health Eur
Pirker W, Ferreira JJ, Rascol O, Poewe W.   +3 more
europepmc   +1 more source

Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex [PDF]

, 2018
Marta Szlachta, Maciej Kuśmider, Paulina Pabian, Joanna Solich, Magdalena Kolasa, Dariusz Żurawek, Marta Dziedzicka‐Wasylewska, Agata Faron‐Górecka   +7 more
openalex   +1 more source

The Role of the Posterior Paraventricular Nucleus of the Thalamus in Food Deprivation‐Induced Heroin‐Seeking Relapse, in Male and Female Rats

Addiction Biology, Volume 31, Issue 1, January 2026.
Chemogenetic inhibition of the pPVT resulted in an increase in food‐deprivation‐induced heroin seeking compared to the control group, only in male rats. Chemogenetic excitation of the pPVT resulted in an increase in heroin seeking under food‐deprivation conditions.
Catarina Borges, Anita Darecka, Amélie Mainville‐Berthiaume, Emily Ah‐Yen, Mahgol Darvishmolla, Richard Courtemanche, Uri Shalev   +6 more
wiley   +1 more source

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review. [PDF]

Front Toxicol
Zhou W, Sun Y, Dai M, Ma S, Lu Q, Qian J, Shang Z, Zhou K, Chen M, Jiang X.   +9 more
europepmc   +1 more source

[In Response to The neuroleptic treatment of schizophrenia: dosing strategies, depot preparations and novel medications by Alexander S. Young, M.D. (volume 13, 18-26)] [PDF]

, 2012
Cassar, Joseph, M.D., Longhurst, James, M.D.   +1 more
core   +1 more source

Documentation of Drug and Non‐Drug Allergies in Public Hospital Electronic Health Records: A National Survey

Clinical &Experimental Allergy, Volume 56, Issue 1, Page 41-52, January 2026.
These surveys reveal inconsistent electronic patient record (EPR) systems and poor documentation standards for non‐drug allergies, leading to high incident rates and misclassification. Standardised documentation, improved training and user‐friendly EPR platforms are urgently needed to enhance patient safety and reduce allergy‐related incidents across ...
Melvin Lee Qiyu, Erika Harnik, Claudia Gore   +2 more
wiley   +1 more source