Results 91 to 100 of about 124,053 (354)

Evaluation of the Community Leadership Project 2.0: Midpoint Report [PDF]

, 2015
The Community Leadership Project (CLP) is a collaborative effort between the David and Lucile Packard Foundation, the James Irvine Foundation, and the William and Flora Hewlett Foundation to build the capacity of small, community-based organizations ...
Allie Bollella, Hanh Cao Yu, Jennifer Henderson-Frakes, Traci Endo Inouye   +3 more
core  

Test Case Generation for Object-Oriented Imperative Languages in CLP

, 2010
Testing is a vital part of the software development process. Test Case Generation (TCG) is the process of automatically generating a collection of test cases which are applied to a system under test.
Albert, ELVIRA ALBERT, Futamura, GERMÁN PUEBLA, MIGUEL GÓMEZ-ZAMALLOA, Müller, Vaziri, Zhao   +7 more
core   +1 more source

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

Advanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong, Wenyan Hao, Lingqi Xu, Yingyi Yang, Zhenzhen Dong, Peng Pan, Zhenjiang Bai, Jie Huang, Kaidi Yang, Zhu Jin, Rui Kang, Qiang Shan, Jiang huai Wang, Zijian Zhou, Daolin Tang, Jian Wang, Huiting Zhou   +16 more
wiley   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

No bounds for the bound book: a digital refresh to reload the page

MatLit, 2019
Recensão crítica de Kiene Brillenburg Wurth, Kári Driscoll e Jessica Pressman (eds.), Book Presence in a Digital Age. London: Bloomsbury Academic, 2018, 280 pp. ISBN 978-1-5013-2118-4.
Reina, Patrícia
doaj   +1 more source

Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage

Advanced Science, EarlyView.
Src reduces neutrophil extracellular traps (NETs) generation and resolves acute organ damage. Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF1/MEK/ERK pathway by mediating PKC phosphorylation.
Guotao Lu, Fei Han, Yaodong Wang, Chenchen Yuan, Qingtian Zhu, Tianqi Xia, Lin Chen, Xiaowu Dong, Yanbing Ding, Weiming Xiao, Yuyan Zhang, Jiajia Pan, Hongwei Xu, Weiwei Chen, Bo Tu, Wei Li, Fei Wang, Weijuan Gong, Lianghao Hu   +18 more
wiley   +1 more source

Endothelial‐Derived CCL7 Promotes Macrophage Polarization and Aggravates Septic Acute Lung Injury via CCR1‐Mediated STAT1 Succinylation

Advanced Science, EarlyView.
During sepsis, pulmonary vascular endothelial cells secrete chemokine CCL7, which plays a pivotal role in facilitating the infiltration of C‐C motif chemokine receptor 1‐positive (CCR1+) macrophages into lung tissue. Activation of the CCL7–CCR1 axis enhances the succinylation of STAT1 mediated by KAT2A, thereby driving metabolic reprogramming and ...
Xue Li, Yuqin Long, Yunxi Zhu, Jiahui Gu, Ping Zhou, Changhong Miao   +5 more
wiley   +1 more source

Humanities in Progress: A Potencialidade do Digital

MatLit, 2017
Recensão crítica de Patrick Svensson e David Theo Goldberg, eds. Between Humanities and the Digital. Cambridge, MA: The MIT Press, 2015. 592 pp. ISBN: 9780262028684.
Marie Claire De Mattia
doaj   +1 more source

Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis

PLoS Pathogens, 2014
Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. We hypothesized that Clp is required for the physiologic turnover of mycobacterial proteins whose accumulation is ...
Ravikiran M. Raju, Mark P. Jedrychowski, Jun-Rong Wei, Jessica T. Pinkham, Annie S. Park, K. O'Brien, Germán Rehren, D. Schnappinger, S. Gygi, E. Rubin   +9 more
semanticscholar   +1 more source

Chlorpyrifos Removal for Wastewater Reuse [PDF]

, 2016
Approximately 1.2 billion people around the world live in areas of physical water scarcity. This could increase to half of the world’s population by 2030 and could displace 24 to 700 million people unless steps are taken to ensure adequate water supply.1
Kamalanathan, Indran
core   +2 more sources