Results 71 to 80 of about 31,869 (248)

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Entre Lisboa e Ingatestone: Revue Ou e Esboços para uma Arqueologia da Poesia Sonora em Portugal

MatLit, 2019
A Revue OU-Cinquème Saison é justamente considerada como uma das mais representativas publicações no âmbito das poéticas experimentais. Publicada entre 1958 e 1974, ao longo de mais de 40 números, ela foi palco de um conjunto extenso de relações entre ...
Neves, Nuno Miguel
doaj   +1 more source

LncRNA NORAD Enhances Inflammatory Injury in Sepsis‐Associated Acute Lung Damage Through miR‐150‐5p/STAT1‐Dependent NF‐κB Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu, Xi‐Xi Chen, Gui‐Hua Wei, Feng Li, Hai‐Yan Zong   +4 more
wiley   +1 more source

“FISIOLOGIA” À PORTUGUESA EM FOLHETIM

Revista de Estudos Literários, 2017
FISIOLOGIAS - Lopes de Mendonça  Introdução por Maria João ...
Maria João Simões
doaj   +1 more source

Assessing and Explaining Human–Nature Coordination at the County Scale in China: Combining an Interpretable Spatiotemporal Graph Neural Network and Difference‐In‐Differences

Land Degradation &Development, EarlyView.
ABSTRACT Coordinating high‐intensity human activities with fragile ecosystems remains a major challenge for global sustainability. Accurate assessment of human–nature coordination (HNC) is critical, yet county‐level variations, underlying drivers, and responses to ecological zoning have seldom been examined simultaneously within a unified framework. We
Qi Liu, Yirong Fan, Mengjuan Li, Bo Li, Jiajun Qiao   +4 more
wiley   +1 more source

Recensão: POESIA COMPLETA — MANOEL DE BARROS

Revista de Estudos Literários, 2016
Recensão crítica de MANOEL DE BARROS, POESIA COMPLETA. Lisboa, Relógio d’Água, 2016. 480 páginas. ISBN: 978-989-641-676-8.
Marisa das Neves Henriques
doaj   +1 more source

A look at clp: Theory and application

Applied Artificial Intelligence, 1997
Constraint logic programming CLP is a relatively new programming paradigm. During its 10 years of existence the theory of CLP has been increasingly understood and the two differ ent approaches domain technology and incremental linear solving have been implemented in various CLP systems.
Július Csontó, Ján Paralic
openaire   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Dehydrodieugenol Neolignans as Multitarget Anti-Inflammatory Agents: sPLA2 Inhibition and Therapeutic Implications

Drugs and Drug Candidates
Background/Objectives: The study investigated the anti-inflammatory potential of neolignan derivatives of dehydrodieugenol (CP1–CP5), focusing on the inhibition of secretory phospholipase A2 (sPLA2), a key enzyme in inflammation.
Adeilso B. Santos Junior, Caroline R. C. Costa, João H. G. Lago, Airam Roggero, Igor N. Oliveira, Danilo R. S. Lima, Paloma P. Borges, Willian H. B. C. Santos, Marcos A. Oliveira, Sérgio F. Sousa, Marcos H. Toyama   +10 more
doaj   +1 more source

Recensão: CERVANTES, ENIGMAS E MITOLOGIAS — PEDRO SOARES MARTÍNEZ

Revista de Estudos Literários, 2011
Recensão crítica de PEDRO SOARES MARTÍNEZ. CERVANTES. ENIGMAS E MITOLOGIAS. Coimbra, Almedina, 2007. 144 páginas. ISBN: 9789724029245.
Alexia Dotras Bravo
doaj   +1 more source