Results 131 to 140 of about 31,869 (248)

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

open access: yesClinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang   +12 more
wiley   +1 more source

Impact of prenatal LPS on sepsis-related neurobiological outcomes. [PDF]

open access: yesMetab Brain Dis
Gava FF   +16 more
europepmc   +1 more source

PondNet – towards a global network of experiments on the effects of climate change on aquatic ecosystems

open access: yesEcography, Volume 2026, Issue 8, August 2026.
Global change is reshaping the distribution of biodiversity and the functioning of ecosystems. Predicting the long‐term consequences of such changes remains a challenge due to a need for a clear understanding of the mechanisms underpinning ecosystem‐level responses, as well as the role of geographical and environmental contingencies.
Miguel G. Matias   +15 more
wiley   +1 more source

Altered Cortical Morphological Brain Networks and Their Diagnostic Classification Utility in Major Depressive Disorder

open access: yesHuman Brain Mapping, Volume 47, Issue 11, 01 August 2026.
Using structural MRI data from over 2700 participants, this large‐scale study shows that major depressive disorder exhibits distinct, feature‐specific alterations across multiple brain structural networks. These changes are already present in first‐episode, drug‐naive patients and allow effective differentiation between individuals with depression and ...
Xuetian Sun   +129 more
wiley   +1 more source

The Interplay of Teacher Agency and TPACK in AI‐Integrated Science Education: Insights From Exemplary Practice Cases

open access: yesJournal of Computer Assisted Learning, Volume 42, Issue 4, August 2026.
ABSTRACT Background Teacher agency plays a pivotal role in technology‐enhanced instruction, yet empirical evidence connecting agency to the practical enactment of specific components of TPACK remains limited. In particular, the intersections between teacher agency and TPK/TCK as enacted practices warrant closer scrutiny.
Hyojoon Kim, Eun‐Jeong Yu
wiley   +1 more source

PRMT5 Mediates Sepsis‐Associated Lung Injury by Modulating JAK1 Arginine Methylation: A Mechanism Study

open access: yesThe Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT Lung injury is a common complication in critical sepsis. PRMT5 is implicated in endothelial inflammation and lung diseases, but its role in sepsis‐associated lung injury remains unclear. This study collected clinical sepsis samples and detected the mRNA expression of PRMT5.
Bo Wang, Zhen Ge, Fei‐Xiang Chen
wiley   +1 more source

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