Results 141 to 150 of about 30,356 (266)

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr   +10 more
wiley   +1 more source

Understanding erythroid physiology and pathology in humanized mice: A closer look

open access: yesBritish Journal of Haematology, EarlyView.
Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu   +7 more
wiley   +1 more source

Spontaneous and pharmacologically induced hypothermia protect mice against endotoxic shock

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Despite the well‐known occurrence of hypothermia during sepsis, its underlying biological nature and adaptive value remain debated. Experimental Approach Using indirect calorimetry, telemetry, thermal gradient studies and pharmacological studies, we examined the thermal and metabolic responses of mice treated with a shock ...
Arely Tinajero   +7 more
wiley   +1 more source

Legislation and Current Practices Concerning Risk Assessment of Skin Sensitizers in the European Union: A Comparative and Survey Study

open access: yesContact Dermatitis, EarlyView.
Through an analysis of EU legislation and questionaries distributed to expert and stakeholders, this paper investigates the legislation and risk assessment process in EU concerning skin sensitizers. Approximately 40% of the participants found the current protection insufficient and multiple areas of improvement were identified and discussed.
Mathias Krogh Pedersen   +7 more
wiley   +1 more source

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