Results 111 to 120 of about 142,078 (306)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

CLUB KIDS

open access: yes, 2017
20. stoljeće kroz svako desetljeće bilo je obilježeno promjenama koje su se najviše očitavale u svijetu mode i glazbe. Od jazz-a i flapper djevojaka u underground barovima 1920-ih u New Yorku do Londonske New Romantics scene 1980-tih ; glazba i moda dva su bitna čimbenika - uz ideologiju i bunt mladih ljudi – za nastanak subkultura ili kontra-kultura ...
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Zápis šesti až osmiletých dětí do kurzů sjezdového lyžování ve Slovinsku Enrolling 6–8 year old children in alpine skiing courses in Slovenia

open access: yesActa Universitatis Palackianae Olomucensis. Gymnica, 2010
<strong>V&Yacute;CHODISKA</strong>: Lyžov&aacute;n&iacute; je sportovn&iacute; aktivitou, kterou vět&scaron;ina dět&iacute; r&aacute;da praktikuje, a proto se r&aacute;dy zapisuj&iacute; do různ&yacute ...
Nina Makuc   +2 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Strength diagnosis in elite Spanish clubs teams [PDF]

open access: gold, 2009
Alejandro Legaz‐Arrese   +2 more
openalex   +1 more source

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