Results 91 to 100 of about 175,554 (301)

TRial to Assess Implementation of New research in a primary care Setting (TRAINS): study protocol for a pragmatic cluster randomised controlled trial of an educational intervention to promote asthma prescription uptake in general practitioner practices

Trials, 2022
Background There is a marked increase in unscheduled care visits in school-aged children with asthma after returning to school in September. This is potentially associated with children not taking their asthma preventer medication during the school ...
Rami A. Alyami, Rebecca Simpson, Phillip Oliver, Steven A. Julious   +3 more
doaj   +1 more source

Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction [PDF]

, 2011
<b>Background</b> Meta-analysis of small trials suggests that pharmacist-led collaborative review and revision of medical treatment may improve outcomes in heart failure.<p></p> <b>Methods and results</b> We studied
Forsyth, P., Greenlaw, N., Jhund, P.S., Lowrie, R., Mair, F.S., McConnachie, A., McMurray, J.J.V., Rae, B.   +7 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Sustainable waiting time reductions after introducing the STAT model for access and triage: 12-month follow up of a stepped wedge cluster randomised controlled trial

BMC Health Services Research, 2020
Background Timely access is a challenge for providers of outpatient and community-based health services, as seen by the often lengthy waiting lists to manage demand.
Katherine E. Harding, David A. Snowdon, Luke Prendergast, Annie K. Lewis, Bridie Kent, Sandy F. Leggat, Nicholas F. Taylor   +6 more
doaj   +1 more source

Implementing telephone triage in general practice: a process evaluation of a cluster randomised controlled trial [PDF]

, 2015
Background: Telephone triage represents one strategy to manage demand for face-to-face GP appointments in primary care. However, limited evidence exists of the challenges GP practices face in implementing telephone triage.
A Fretheim, Anna Varley, B McKinstry, B McKinstry, C Pope, C Pope, Chris Salisbury, Colin Green, CR May, D Richards, DA Richards, David A Richards, Emily Fletcher, H Boon, I Holmstrom, J Green, J Murdoch, Jamie Murdoch, John L Campbell, Linnie Price, LS Meredith, M Jiwa, NB Baskerville, NC Campbell, Nicky Britten, P Craig, P Hawe, Raff Calitri, Rod S Taylor, RP Hermens, S Flottorp, SR Poole, Suzanne H Richards, V Lattimer, Valerie Lattimer   +34 more
core   +2 more sources

Cultural respect in general practice: a cluster randomised controlled trial [PDF]

Medical Journal of Australia, 2019
To the Editor: We refer to Liaw and colleagues’1 recently published study in the Journal. We acknowledge the positive intentions and rigour of this trial, and empathically concur with Thompson and Thackrah's2 comment that the results of this research “[do] not mean that efforts to improve cultural competence in health care settings should be abandoned”.
Hickey, Sophie, West, Roianne
openaire   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The clinical and cost-effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime (the VIP trial): study protocol for a randomised controlled trial. [PDF]

, 2020
BACKGROUND: Older people are vulnerable to sustained high levels of psychosocial distress following a crime. A cognitive behavioural therapy (CBT)-informed psychological therapy, the Victim Improvement Package (VIP) may aid recovery.
Andrew, D, Aspden, T, Blanchard, M, Brewin, CR, Buszewicz, M, Cuming-Higgs, J, Drennan, V, Hunter, R, Kessel, A, Laycock, G, Leavey, G, O'Keeffe, A, Riveros, M, Satchell, J, Serfaty, M   +14 more
core   +6 more sources

Cluster randomisation trials in mental health research [PDF]

Evidence Based Mental Health, 2000
The unit of allocation in most clinical trials is the individual patient. However, experimental trials in which the unit of allocation is an intact cluster of participants (eg, families, schools, medical practices, communities) are becoming increasingly widespread in the evaluation of healthcare and educational interventions.
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source