Results 101 to 110 of about 175,554 (301)

A collaborative care psychosocial intervention to improve late life depression in socioeconomically deprived areas of Guarulhos, Brazil: the PROACTIVE cluster randomised controlled trial protocol

Trials, 2020
Background The elderly population has been growing in most low- and middle-income countries (LMIC), and depression is a common condition among these populations.
Marcia Scazufca, Carina Akemi Nakamura, Tim J. Peters, Maiara Garcia Henrique, Antônio Seabra, Ehidee Gomez La Rotta, Renato M. Franzin, Daniele Ferreira Martins, Pepijn Van de Ven, William Hollingworth, Ricardo Araya   +10 more
doaj   +1 more source

Missing Data in Cluster Randomised Trials [PDF]

, 2017
Missing outcomes are a commonly occurring problem in cluster randomised trials, which can lead to biased and inefficient inference if ignored or handled inappropriately. Handling missing data in CRTs is complicated due to the hierarchical structure of the data. Two approaches for analysing such trials are cluster-level analysis and individual level
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The impact of training non-physician clinicians in Malawi on maternal and perinatal mortality : a cluster randomised controlled evaluation of the enhancing training and appropriate technologies for mothers and babies in Africa (ETATMBA) project [PDF]

, 2012
Background: Maternal mortality in much of sub-Saharan Africa is very high whereas there has been a steady decline in over the past 60 years in Europe. Perinatal mortality is 12 times higher than maternal mortality accounting for about 7 million neonatal
A Wilson, C McCord, C Pereira, C Pereira, C Pope, Chisale Mhango, D Ellard, David Davies, David Ellard, Doug Simkiss, E McAuliffe, F Mullan, Francis Kamwendo, G Chilopora, J Bryce, J Ritchie, Joseph Paul O’Hare, K Hill, Ministry of Health, National Statistical Office (NSO), and ICF Macro, Ngianga-bakwin Kandala, S Bergstrom, S Bradley, S Niermeyer, Siobhan Quenby, W Graham, W Graham, World Health Organization, UNICEF, UNFPA, and The World Bank   +27 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Raising the standard of applied dementia care research : addressing the implementation error [PDF]

, 2014
Editoria
Moniz-Cook, Esme, Vernooij-Dassen, Myrra
core   +2 more sources

Spatial Analysis of Cluster Randomised Trials [PDF]

, 2018
Cluster randomised trials (CRTs) often use geographical areas as the unit of randomisation. Despite this, explicit consideration of the location and spatial distribution of observations is rare. In many trials, the location of participants will have little importance, however in some, especially against infectious diseases, spillover effects due to ...
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Action 3:30R: protocol for a cluster randomised feasibility study of a revised teaching assistant-led extracurricular physical activity intervention for 8- to 10-year-olds

Pilot and Feasibility Studies, 2017
Background Approximately half of 7-year-old children do not meet physical activity (PA) recommendations. Interventions targeting primary school children’s afterschool discretionary time could increase PA.
Byron Tibbitts, Alice Porter, Simon J. Sebire, Chris Metcalfe, Emma Bird, Jane Powell, Russell Jago   +6 more
doaj   +1 more source

Sexually transmitted infection as a risk factor for homosexual HIV transmission: a systematic review of epidemiological studies

, 2000
Existing reviews suggest some sexually transmitted infections (STIs) are risk factors in heterosexual HIV transmission. This may not be so in homosexual HIV transmission, about which reviews make no specific conclusions.
Bonell, C, Hickson, F, Weatherburn, P
core   +1 more source