Results 121 to 130 of about 404,795 (397)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Inadequate reporting of research ethics review and informed consent in cluster randomized trials : review of random sample of published trials [PDF]

, 2011
Peer reviewedPublisher ...
Bennett, Carol, Boruch, Robert F, Brehaut, Jamie C, Dixon, Stephanie, Donner, Allan, Eccles, Martin P, Grimshaw, Jeremy M, McRae, Andrew D, Saginur, Raphael, Skea, Zoe, Taleban, Julia, Taljaard, Monica, Weijer, Charles   +12 more
core   +2 more sources

Integrated community-based HIV and non-communicable disease care within microfinance groups in Kenya: study protocol for the Harambee cluster randomised trial [PDF]

, 2021
Becky L. Genberg, Juddy Wachira, Jon A. Steingrimsson, Sonak Pastakia, Dan N. Tran, Jamil Said, Paula Braitstein, Joseph W. Hogan, Rajesh Vedanthan, Suzanne Goodrich, Catherine Kafu, Marta Wilson‐Barthes, Omar Galárraga   +12 more
openalex   +1 more source

The CORE service improvement programme for mental health crisis resolution teams: results from a cluster-randomised trial

British Journal of Psychiatry, 2019
Background Crisis resolution teams (CRTs) offer brief, intensive home treatment for people experiencing mental health crisis. CRT implementation is highly variable; positive trial outcomes have not been reproduced in scaled-up CRT care.
B. Lloyd-Evans, D. Osborn, L. Marston, Danielle Lamb, G. Ambler, R. Hunter, O. Mason, S. Sullivan, C. Henderson, S. Onyett, Elaine Johnston, N. Morant, F. Nolan, K. Kelly, Marina Christoforou, Kate Fullarton, Rebecca Forsyth, Michael Davidson, Jonathan Piotrowski, E. Mundy, G. Bond, Sonia Johnson   +21 more
semanticscholar   +1 more source

Cultural respect in general practice: a cluster randomised controlled trial [PDF]

Medical Journal of Australia, 2019
To the Editor: We refer to Liaw and colleagues’1 recently published study in the Journal. We acknowledge the positive intentions and rigour of this trial, and empathically concur with Thompson and Thackrah's2 comment that the results of this research “[do] not mean that efforts to improve cultural competence in health care settings should be abandoned”.
Hickey, Sophie, West, Roianne
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A collaborative care psychosocial intervention to improve late life depression in socioeconomically deprived areas of Guarulhos, Brazil: the PROACTIVE cluster randomised controlled trial protocol

Trials, 2020
Background The elderly population has been growing in most low- and middle-income countries (LMIC), and depression is a common condition among these populations.
Marcia Scazufca, Carina Akemi Nakamura, Tim J. Peters, Maiara Garcia Henrique, Antônio Seabra, Ehidee Gomez La Rotta, Renato M. Franzin, Daniele Ferreira Martins, Pepijn Van de Ven, William Hollingworth, Ricardo Araya   +10 more
doaj   +1 more source

An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial [PDF]

, 2015
Objective To evaluate the clinical efficacy of an established programme of occupational therapy in maintaining functional activity and reducing further health risks from inactivity in care home residents living with stroke sequelae.
Barton, Garry, Burton, C. R., Burton, Christopher R., Fletcher-Smith, J., Fletcher-Smith, Joanna, Irvine, L., Irvine, Lisa, Lett, K., Mant, J., Mant, Jonathan, Masterson-Algar, Patricia, Peryer, G., Peryer, Guy, Rashid, Farzana, Roalfe, A. K., Roalfe, Andrea K., Sackley, Catherine M., Sharp, L., Sharp, Leslie, Sheehan, B., Sheehan, Bart, Stant, K. E., Stant, Katie E., Steel, Kerry, Steele, K., Walker, M. F., Walker, Marion F., Watkins, C. L., Watkins, Caroline L., Wheatley, K., Wheatley, Keith, Wilde, K., Wilde, Kate, Williams, Jane   +33 more
core   +5 more sources

Incorporating parent, former patient and clinician perspectives in the design of a national UK double-cluster, randomised controlled trial addressing uncertainties in preterm nutrition [PDF]

, 2021
William Lammons, Becky Moss, Cheryl Battersby, Victoria Cornelius, Daphne Babalis, Neena Modi   +5 more
openalex   +1 more source

PrEP Implementation for Mothers in Antenatal Care (PrIMA): study protocol of a cluster randomised trial

BMJ Open, 2019
Introduction Women in regions with high HIV prevalence are at high risk of HIV acquisition during pregnancy and postpartum, and acute maternal HIV contributes a substantial proportion of infant HIV infections.
J. Dettinger, J. Kinuthia, J. Pintye, Nancy Mwongeli, Laurén Gómez, B. Richardson, R. Barnabas, A. Wagner, Gabrielle E. O'Malley, J. Baeten, G. John-Stewart   +10 more
semanticscholar   +1 more source