Results 131 to 140 of about 404,795 (397)
Cluster randomisation trials in mental health research [PDF]
Evidence Based Mental Health, 2000 The unit of allocation in most clinical trials is the individual patient. However, experimental trials in which the unit of allocation is an intact cluster of participants (eg, families, schools, medical practices, communities) are becoming increasingly widespread in the evaluation of healthcare and educational interventions.
openaire +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Cascade diagrams for depicting complex interventions in randomised trials [PDF]
, 2013 Many medical interventions—particularly non-pharmacological ones—are complex, consisting of multiple interacting components targeted at different organisational levels.1 2 Published descriptions of complex interventions often do not contain enough ...
Bremner, Stephen A. +4 more
core +1 more source
British medical journal, 2020 Objective To evaluate the effects of a computerised decision support tool for comprehensive drug review in elderly people with polypharmacy. Design Pragmatic, multicentre, cluster randomised controlled trial.
Anja Rieckert +16 more
semanticscholar +1 more source
Missing Data in Cluster Randomised Trials [PDF]
, 2017 Missing outcomes are a commonly occurring problem in cluster randomised trials, which can lead to biased and inefficient inference if ignored or handled inappropriately. Handling missing data in CRTs is complicated due to the hierarchical structure of the data. Two approaches for analysing such trials are cluster-level analysis and individual level
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Raising the standard of applied dementia care research : addressing the implementation error [PDF]
, 2014 Editoria
Moniz-Cook, Esme, Vernooij-Dassen, Myrra
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Pilot and Feasibility Studies, 2017 Background Approximately half of 7-year-old children do not meet physical activity (PA) recommendations. Interventions targeting primary school children’s afterschool discretionary time could increase PA.
Byron Tibbitts +6 more
doaj +1 more source
British Journal of Sports Medicine, 2020 Background Cardiorespiratory fitness (CRF) is an important marker of current and future health status. The primary aim of our study was to evaluate the impact of a time-efficient school-based intervention on older adolescents’ CRF.
D. Lubans +18 more
semanticscholar +1 more source