Results 141 to 150 of about 404,795 (397)

Spatial Analysis of Cluster Randomised Trials [PDF]

, 2018
Cluster randomised trials (CRTs) often use geographical areas as the unit of randomisation. Despite this, explicit consideration of the location and spatial distribution of observations is rare. In many trials, the location of participants will have little importance, however in some, especially against infectious diseases, spillover effects due to ...
openaire   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Managing Injuries of the Neck Trial (MINT): design of a randomised controlled trial of treatments for whiplash associated disorders

BMC Musculoskeletal Disorders, 2007
Background A substantial proportion of patients with whiplash injuries develop chronic symptoms. However, the best treatment of acute injuries to prevent long-term problems is uncertain.
Williamson Esther M, Williams Mark A, Szczepura Ala, Ashby Deborah, Cooke Matthew W, Underwood Martin R, Gates Simon, Lamb Sarah E, Withers Emma J, Mt Isa Shahrul, Gumber Anil   +10 more
doaj   +1 more source

A cluster randomised control trial of a multi-component weight management programme for adults with intellectual disabilities and obesity [PDF]

, 2017
There have been few published controlled studies of multi-component weight management programmes that include an energy deficit diet (EDD), for adults with intellectual disabilities and obesity.
Boyle, Susan, Hankey, Catherine, Harris, Leanne, Jones, Nathalie, Melville, Craig, Murray, Heather, Pert, Carol, Tobin, Janet   +7 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

GestationaL Obesity Weight management: Implementation of National Guidelines (GLOWING): a pilot cluster randomised controlled trial of a guideline implementation intervention for the management of maternal obesity by midwives

Pilot and Feasibility Studies, 2018
Background Weight management in pregnancy guidelines exist, although dissemination alone is an ineffective means of implementation. Midwives identify the need for support to overcome complex barriers to practice.
Nicola Heslehurst, Judith Rankin, Catherine McParlin, Falko F. Sniehotta, Denise Howel, Stephen Rice, Elaine McColl   +6 more
doaj   +1 more source

Embedded motivational interviewing combined with a smartphone app to increase physical activity in people with sub-acute low back pain: study protocol of a cluster randomised control trial [PDF]

, 2019
Background: Motivational Interviewing is an evidence-based, client-centred counselling technique that has been used effectively to increase physical activity, including for people with low back pain.
Breckon, Jeff, Davidson, M, Holden, J, Monfries, M, O’ Halloran, PD, Rahayu, W, Taylor, NF   +6 more
core   +2 more sources

Impact of scheduling multiple outdoor free-play periods in childcare on child moderate-to-vigorous physical activity: a cluster randomised trial

International Journal of Behavioral Nutrition and Physical Activity, 2018
BackgroundIncreasing the frequency of periods of outdoor free-play in childcare may represent an opportunity to increase child physical activity. This study aimed to assess the efficacy of scheduling multiple periods of outdoor free-play in increasing ...
L. Razak, S. Yoong, J. Wiggers, P. Morgan, Jannah Jones, M. Finch, R. Sutherland, Christophe Lecathelnais, K. Gillham, Tara Clinton-McHarg, L. Wolfenden   +10 more
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Sexually transmitted infection as a risk factor for homosexual HIV transmission: a systematic review of epidemiological studies

, 2000
Existing reviews suggest some sexually transmitted infections (STIs) are risk factors in heterosexual HIV transmission. This may not be so in homosexual HIV transmission, about which reviews make no specific conclusions.
Bonell, C, Hickson, F, Weatherburn, P
core   +1 more source