Results 161 to 170 of about 404,795 (397)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study)

Trials, 2011
Background The purpose of this research is to develop and evaluate methods for conducting cluster randomised trials in a primary care database that contains electronic patient records for large numbers of family practices.
Charlton Judith, Ashworth Mark, McCann Gerard, Dregan Alex, McDermott Lisa, van Staa Tjeerd, Gulliford Martin C, Grieve Andrew P, Little Paul, Moore Michael V, Yardley Lucy   +10 more
doaj   +1 more source

Evaluation of the impact of a school gardening intervention on children's fruit and vegetable intake: a randomised controlled trial. [PDF]

, 2014
Background: Current academic literature suggests that school gardening programmes can provide an interactive environment with the potential to change children’s fruit and vegetable intake.
A Hackett, A Harding, A Magarey, A Timperio, AJ Vickers, AM Craigie, AR Ness, C Devine, C Knai, Camilla Nykjaer, CE Evans, CE Evans, Charlotte EL Evans, E Van Cauwenberghe, EJ Ozer, J Connolly, J Morris, J Rasbash, JA O’Dea, Janet E Cade, JD McAleese, JE Cade, JN Davis, K Block, L Lautenschlager, L Lautenschlager, LA Bazzano, M Christian, M Maynard, M Nelson, MC Wang, Meaghan S Christian, MM Ratcliffe, MS Christian, MS Kitchen, MSEC Christian, Neil Hancock, P Boffetta, PJ Morgan, R Passy, R Robinson-O’Brien, S Koch, S Lineberger, S O’Brien, S Poston, S Somerset, S Somerset, SM Parmer, T Baranowski   +48 more
core   +2 more sources

Identifying Child Anxiety Through Schools – identification to intervention (iCATS-i2i): protocol for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice [PDF]

, 2022
Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence, Paul Stallard, Jason Stainer, Lucy Taylor, Victoria Williamson, Emily Day, Jennifer Fisk, Iheoma Green, Gemma Halliday, Ciara Hennigan, Samantha Pearcey, Olly Robertson, Cathy Creswell   +27 more
openalex   +1 more source

Cluster randomised trials [PDF]

BMJ, 1999
N. Freemantle, J. Wood, M. K Campbell, J. M Grimshaw   +3 more
openaire   +1 more source

Community-led trials: Intervention co-design in a cluster randomised controlled trial [PDF]

BMC Public Health, 2017
In conventional randomised controlled trials (RCTs), researchers design the interventions. In the Camino Verde trial, each intervention community designed its own programmes to prevent dengue. Instead of fixed actions or menus of activities to choose from, the trial randomised clusters to a participatory research protocol that began with sharing and ...
openaire   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction [PDF]

, 2011
<b>Background</b> Meta-analysis of small trials suggests that pharmacist-led collaborative review and revision of medical treatment may improve outcomes in heart failure.<p></p> <b>Methods and results</b> We studied
Forsyth, P., Greenlaw, N., Jhund, P.S., Lowrie, R., Mair, F.S., McConnachie, A., McMurray, J.J.V., Rae, B.   +7 more
core   +1 more source

Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)

British medical journal, 2017
Objective To compare the effectiveness of insulin pumps with multiple daily injections for adults with type 1 diabetes, with both groups receiving equivalent training in flexible insulin treatment.
S. Heller, J. Elliott, N. Waugh, S. Amiel, P. Choudhary, M. Evans, F. Green, P. Hammond, A. Jaap, B. Kennon, R. Lindsay, P. Mansell, J. Baillie, A. Beckwith, H. Brown, K. Callaby, Katy Davenport, S. Donald, L. Faghahati, S. Hartnell, A. Housden, K. Pabla, N. Croxon, S. Macdonald, M. Mohammed, V. Steel, K. Valentine, P. Young, A. Boal, P. Clerkin, L. Doran, J. Flynn, E. Gibb, H. Peddie, B. Quinn, H. Rogers, J. Shephard, J. Carling, A. Collins, L. Dinning, C. Hare, J. Lodge, S. Ray, D. Brown, J. Farmer, A. Cox, C. Cheyette, L. East, J. Ellul, K. Hunt, K. Shaw, B. Stothard, L. Diamond, L. Aniello, D. Anderson, K. Cockerell, V. Heaney, A. Hutchison, N. Zammitt, G. Babington, G. Bird, J. Evans, T. Gazis, N. Maude, K. Nunnick, D. Spick, L. Fenn, C. Gianfrancesco, V. Gordon, L. Greaves, S. Hudson, V. Naylor, C. Nisbet, Carolin Taylor, K. Towse, C. Ward, C. Cooper, M. Dimairo, Ellen Lee, D. White, G. Hackney, D. Papaioannou, E. Whatley, M. Bradburn, Michael J. Campbell, H. Basarir   +85 more
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source