Results 11 to 20 of about 175,435 (182)

Registry randomised trials: a methodological perspective

open access: yesBMJ Open, 2023
Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a ...
Christopher M Reid   +13 more
doaj   +1 more source

A study protocol for a cluster-randomised controlled trial of smartphone-activated first responders with ultraportable defibrillators in out-of-hospital cardiac arrest: The First Responder Shock Trial (FIRST)

open access: yesResuscitation Plus, 2023
Objective: To describe the First Responder Shock Trial (FIRST), which aims to determine whether equipping frequently responding, smartphone-activated (GoodSAM) first responders with an ultraportable AED can increase 30-day survival rates in OHCA. Methods:
Verity Todd   +14 more
doaj   +1 more source

Methodological bias in cluster randomised trials [PDF]

open access: yesBMC Medical Research Methodology, 2005
Abstract Background Cluster randomised trials can be susceptible to a range of methodological problems. These problems are not commonly recognised by many researchers. In this paper we discuss the issues that can lead to bias in cluster trials. Methods
Hahn, Seokyung   +3 more
openaire   +5 more sources

How to design efficient cluster randomised trials [PDF]

open access: yesBMJ, 2017
Cluster randomised trials have diminishing returns in power and precision as cluster size increases. Making the cluster a lot larger while keeping the number of clusters fixed might yield only a very small increase in power and precision, owing to the intracluster correlation.
Hemming, K   +4 more
openaire   +3 more sources

Baseline testing in cluster randomised controlled trials: should this be done?

open access: yesBMC Medical Research Methodology, 2019
Background Comparisons of baseline covariates in randomised controlled trials whilst often undertaken is regarded by many as an exercise in futility.
Jaime E. Bolzern   +2 more
doaj   +1 more source

Exploring demographic and lifestyle associations with patient experience following telephone triage by a primary care doctor or nurse:secondary analyses from a cluster randomised controlled trial [PDF]

open access: yes, 2015
The ESTEEM trial was a cluster randomised controlled trial that compared two telephone triage management systems (general practitioner (GP) or a nurse supported by computer decision support software) with usual care, in response to a request for same-day
Bunn   +18 more
core   +2 more sources

Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): study protocol for a randomised, stepped-wedge cluster trial within the EFFECTS trial

open access: yesTrials, 2018
Background Many randomised controlled trials (RCTs) fail to meet their recruitment goals in time. Trialists are advised to include study recruitment strategies within their trials. EFFECTS is a Swedish, academic-led RCT of fluoxetine for stroke recovery.
Erik Lundström   +4 more
doaj   +1 more source

Contamination in complex healthcare trials:the falls in care homes (FinCH) study experience [PDF]

open access: yes, 2020
BACKGROUND: Trials are at risk of contamination bias which can occur when participants in the control group are inadvertently exposed to the intervention.
Allen, F   +8 more
core   +1 more source

Protocol for a cluster randomised controlled feasibility study of Prehospital Optimal Shock Energy for Defibrillation (POSED)

open access: yesResuscitation Plus, 2022
Aims: The Prehospital Optimal Shock Energy for Defibrillation (POSED) study will assess the feasibility of conducting a cluster randomised controlled study of clinical effectiveness in UK ambulance services to identify the optimal shock energy for ...
Helen Pocock   +9 more
doaj   +1 more source

Friendship Bench trial: lay worker training in problem-solving therapy to reduce symptoms of common mental disorders [PDF]

open access: yes, 2015
The Friendship Bench trial is a cluster-randomised trial of the effect of problem-solving therapy training for lay workers on symptoms of common mental disorders among clinic attenders in Harare, Zimbabwe. This dataset enables replication of analysis for
Abas, Melanie   +13 more
core   +1 more source

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