Results 11 to 20 of about 175,275 (300)

Group sequential designs for stepped-wedge cluster randomised trials. [PDF]

Clinical Trials, 2017
BACKGROUND/AIMS: The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design of stepped-wedge cluster ...
Grayling, Michael J, Mander, Adrian P, Wason, James Ms   +2 more
core   +5 more sources

The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial [PDF]

BMC Family Practice, 2016
Background: Despite improving evidence-based practice following clinical guidelines to optimise drug therapy, Type 2 diabetes (T2DM) still exerts a devastating toll from vascular complications and premature death.
Adamson, Ashley, Barnes, Alison, Brosnahan, Naomi, Ford, Ian, Hollingsworth, Kieren G., Kean, Sharon, Lean, Mike E.J., Leslie, Wilma S., Mathers, John C., McCombie, Louise, McIlvenna, Yvonne, Peters, Carl, Rehackova, Lucia, Rodrigues, Angela, Ross, Hazel, Sattar, Naveed, Sniehotta, Falko F., Taylor, Roy, Thom, George, Zhyzhneuskaya, Sviatlana   +19 more
core   +8 more sources

Cluster randomised trials [PDF]

Epidemiology and Psychiatric Sciences, 2011
Although randomised controlled trials are the reference methodology to assess the effects of therapeutic interventions, for interventions that naturally occur in groups of individuals random allocation of participants may be inappropriate. In these cases, the unit of random allocation may be the group or cluster, rather than the individual.
BARBUI, Corrado, CIPRIANI, Andrea
openaire   +4 more sources

Methodological bias in cluster randomised trials [PDF]

BMC Medical Research Methodology, 2005
Abstract Background Cluster randomised trials can be susceptible to a range of methodological problems. These problems are not commonly recognised by many researchers. In this paper we discuss the issues that can lead to bias in cluster trials. Methods
Hahn, Seokyung, Puffer, Suezann, Torgerson, David J, Watson, Judith   +3 more
openaire   +5 more sources

Contamination in trials: is cluster randomisation the answer? [PDF]

BMJ, 2001
Most randomised trials allocate individual participants to different treatments. However, cluster randomised trials in which groups of subjects are allocated to different treatments are becoming increasingly popular.1 Cluster randomisation is often advocated to minimise treatment “contamination” between intervention and control participants.
Torgerson, D J
core   +6 more sources

How to design efficient cluster randomised trials [PDF]

BMJ, 2017
Cluster randomised trials have diminishing returns in power and precision as cluster size increases. Making the cluster a lot larger while keeping the number of clusters fixed might yield only a very small increase in power and precision, owing to the intracluster correlation.
Hemming, K, Eldridge, S, Forbes, G, Weijer, C, Taljaard, M   +4 more
openaire   +3 more sources

Exploring demographic and lifestyle associations with patient experience following telephone triage by a primary care doctor or nurse:secondary analyses from a cluster randomised controlled trial [PDF]

, 2015
The ESTEEM trial was a cluster randomised controlled trial that compared two telephone triage management systems (general practitioner (GP) or a nurse supported by computer decision support software) with usual care, in response to a request for same-day
Bunn, Campbell, Campbell, Campbell, Campbell, Kontopantelis, Lyratzopoulos, McKinstry, Mead, Murdoch, Murdoch, Paddison, Paddison, Richards, Richards, Salisbury, Stirewalt, van Uden, Warren   +18 more
core   +2 more sources

Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): study protocol for a randomised, stepped-wedge cluster trial within the EFFECTS trial

Trials, 2018
Background Many randomised controlled trials (RCTs) fail to meet their recruitment goals in time. Trialists are advised to include study recruitment strategies within their trials. EFFECTS is a Swedish, academic-led RCT of fluoxetine for stroke recovery.
Erik Lundström, Eva Isaksson, Per Wester, Ann-Charlotte Laska, Per Näsman   +4 more
doaj   +1 more source

Protocol for a cluster randomised controlled feasibility study of Prehospital Optimal Shock Energy for Defibrillation (POSED)

Resuscitation Plus, 2022
Aims: The Prehospital Optimal Shock Energy for Defibrillation (POSED) study will assess the feasibility of conducting a cluster randomised controlled study of clinical effectiveness in UK ambulance services to identify the optimal shock energy for ...
Helen Pocock, Charles D. Deakin, Ranjit Lall, Felix Michelet, Abraham Contreras, Mark Ainsworth-Smith, Phil King, Anne Devrell, Debra E. Smith, Gavin D. Perkins   +9 more
doaj   +1 more source

Friendship Bench trial: lay worker training in problem-solving therapy to reduce symptoms of common mental disorders [PDF]

, 2015
The Friendship Bench trial is a cluster-randomised trial of the effect of problem-solving therapy training for lay workers on symptoms of common mental disorders among clinic attenders in Harare, Zimbabwe. This dataset enables replication of analysis for
Abas, Melanie, Araya, Ricardo, Bere, Concilia, Chapoterera, Georgina, Chibanda, Dixon, Dzapasi, Lloyd, Gibson, Lorna, Goba, Nyaradzo, Gumunyu, Tichaona, Munetsi, Epiphany, Rusakaniko, Simbarashe, Simms, Victoria, Verhey, Ruth, Weiss, Helen   +13 more
core   +1 more source