Results 191 to 200 of about 404,795 (397)

Population deworming every 6 months with albendazole in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial [PDF]

, 2013
Shally Awasthi, Richard Peto, Simon Read, Susan Richards, Vinod Kumar Pande, Donald A. P. Bundy, the DEVTA team   +6 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

The Lancet, 2017
M. Lean, W. Leslie, A. Barnes, Naomi Brosnahan, G. Thom, Louise McCombie, C. Peters, S. Zhyzhneuskaya, A. Al-Mrabeh, K. Hollingsworth, Angela M Rodrigues, L. Rehackova, A. Adamson, F. Sniehotta, J. Mathers, H. Ross, Yvonne McIlvenna, Renae J Stefanetti, M. Trenell, P. Welsh, S. Kean, I. Ford, A. McConnachie, N. Sattar, Roy Taylor   +24 more
semanticscholar   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial.

The Lancet Diabetes and Endocrinology, 2019
M. Lean, W. Leslie, A. Barnes, Naomi Brosnahan, G. Thom, Louise McCombie, C. Peters, S. Zhyzhneuskaya, A. Al-Mrabeh, K. Hollingsworth, Angela M Rodrigues, L. Rehackova, A. Adamson, F. Sniehotta, J. Mathers, H. Ross, Yvonne McIlvenna, P. Welsh, S. Kean, I. Ford, A. McConnachie, C. Messow, N. Sattar, Roy Taylor   +23 more
semanticscholar   +1 more source

Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration

British medical journal
This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups of individuals (known as clusters) to different ...
Joanne E McKenzie, M. Taljaard, K. Hemming, Sarah J Arnup, B. Giraudeau, S. Eldridge, Richard Hooper, B. Kahan, Tianjing Li, D. Moher, Elizabeth L Turner, J. Grimshaw, Andrew B Forbes   +12 more
semanticscholar   +1 more source

Cluster randomised trials: useful for interventions delivered to groups [PDF]

BJOG: An International Journal of Obstetrics & Gynaecology, 2018
Karla, Hemming, Alan, Girling
openaire   +2 more sources