Results 61 to 70 of about 175,554 (301)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Rojiroti microfinance and child nutrition: a cluster randomised trial [PDF]

Archives of Disease in Childhood, 2019
ObjectiveTo determine whether Rojiroti microfinance, for poor Indian women, improves child nutrition.DesignCluster randomised trial.SettingTolas (village communities) in Bihar State.ParticipantsWomen and children under 5 years.InterventionsWith Rojiroti microfinance, women form self-help groups and save their money to provide loans to group members ...
Shalini Ojha, Lisa Szatkowski, Ranjeet Sinha, Gil Yaron, Andrew Fogarty, Stephen John Allen, Sunil Choudhary, Alan Robert Smyth   +7 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Update to: Assessing the efficacy of male Wolbachia-infected mosquito deployments to reduce dengue incidence in Singapore

Trials
Background This trial is a parallel, two-arm, non-blinded cluster randomised controlled trial that is under way in Singapore, with the aim of measuring the efficacy of male Wolbachia-infected Aedes aegypti deployments in reducing dengue incidence in an ...
Jue Tao Lim, Diyar Mailepessov, Chee-Seng Chong, Chia-Chen Chang, Borame Dickens, Yee Ling Lai, Lu Deng, Caleb Lee, Li Yun Tan, Grace Chain, Soon Hoe Ho, Muhammad Faizal Zulkifli, Jonathan Liew, Kathryn Vasquez, Vernon Lee, Judith Chui Ching Wong, Shuzhen Sim, Cheong Huat Tan, Lee Ching Ng   +18 more
doaj   +1 more source

Cascade diagrams for depicting complex interventions in randomised trials [PDF]

, 2013
Many medical interventions—particularly non-pharmacological ones—are complex, consisting of multiple interacting components targeted at different organisational levels.1 2 Published descriptions of complex interventions often do not contain enough ...
Bremner, Stephen A., Eldridge, Sandra, Froud, Robert J., Hooper, R., Perera, R.   +4 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A simple and effective method for simulating nested exchangeable correlated binary data for longitudinal cluster randomised trials

BMC Medical Research Methodology
Background Simulation is an important tool for assessing the performance of statistical methods for the analysis of data and for the planning of studies.
Rhys A. Bowden, Jessica Kasza, Andrew B. Forbes   +2 more
doaj   +1 more source

A scoping review of the problems and solutions associated with contamination in trials of complex interventions in mental health

BMC Medical Research Methodology, 2019
Background In a randomised controlled trial, contamination is defined as the receipt of active intervention amongst participants in the control arm.
Nicholas Magill, Ruth Knight, Paul McCrone, Khalida Ismail, Sabine Landau   +4 more
doaj   +1 more source

Evaluation of the impact of a school gardening intervention on children's fruit and vegetable intake: a randomised controlled trial. [PDF]

, 2014
Background: Current academic literature suggests that school gardening programmes can provide an interactive environment with the potential to change children’s fruit and vegetable intake.
A Hackett, A Harding, A Magarey, A Timperio, AJ Vickers, AM Craigie, AR Ness, C Devine, C Knai, Camilla Nykjaer, CE Evans, CE Evans, Charlotte EL Evans, E Van Cauwenberghe, EJ Ozer, J Connolly, J Morris, J Rasbash, JA O’Dea, Janet E Cade, JD McAleese, JE Cade, JN Davis, K Block, L Lautenschlager, L Lautenschlager, LA Bazzano, M Christian, M Maynard, M Nelson, MC Wang, Meaghan S Christian, MM Ratcliffe, MS Christian, MS Kitchen, MSEC Christian, Neil Hancock, P Boffetta, PJ Morgan, R Passy, R Robinson-O’Brien, S Koch, S Lineberger, S O’Brien, S Poston, S Somerset, S Somerset, SM Parmer, T Baranowski   +48 more
core   +2 more sources

Demystifying estimands in cluster-randomised trials

Statistical Methods in Medical Research
Estimands can help clarify the interpretation of treatment effects and ensure that estimators are aligned with the study's objectives. Cluster-randomised trials require additional attributes to be defined within the estimand compared to individually randomised trials, including whether treatment effects are marginal or cluster-specific, and whether ...
Brennan C Kahan, Bryan S Blette, Michael O Harhay, Scott D Halpern, Vipul Jairath, Andrew Copas, Fan Li   +6 more
openaire   +4 more sources